Change Order Manager

Remote, United Kingdom; Homeworking
14 Sep 2022
14 Oct 2022
Full Time
Experienced (non-manager)

Simbec-Orion is a responsive and agile full-service CRO, with wide therapeutic experience and specialist expertise in clinical pharmacology, oncology and rare diseases. Perfectly structured, we provide full-service clinical development solutions for small and mid-size drug developers - headed up by a centralised leadership team.

With a focus on tailormade and scalable solutions, we’ll adapt our delivery style, communications and operations to suit the demands of the project, helping clients achieve their clinical and commercial objectives. Because our goal is the same as theirs; to improve patients’ lives.


We are looking for a Change Order Manager to join our Group Finance Department where you will be reporting into the SCOM, will work as part of the Change Order Management Team in preparing and delivering changes to study budgets arising from out of scope activities and executing the associated contractual amendment. You will work closely with functional groups (e.g. Project Management, Clinical Operations, Data Management), Finance & Contracts, and Sponsors to effectively drive the change order processes. You will have a fundamental role in contributing to project profitability, maximising project revenue potential, ensuring minimal revenue leakage and generating positive cash flow for our work via robust change order payment scheduling.


  • Facilitate Project Management, Finance and Contracts departments’ identification of out of scope activities on assigned projects to ensure there is minimal revenue leakage.
  • Support Project Management and Finance in relation to all appropriate processes aimed at maximising revenue and supporting a cash neutral study position, including providing cash flow analyses and renegotiating Payment Schedules.
  • Manage the Sponsor Change Order Notification Letter (CNF) and Change Order (CO) processes on assigned projects within required timelines and ensure all functions are informed of status & progress.
  • Coordinate input from operational departments on assigned Projects to understand and model out-of-scope budget amendments to projects and work effectively with all relevant departments to obtain signed client agreements within the required timeframe from initial identification to ensure a healthy client balance is maintained.
  • Work with Head of COM & SCOM to drive Sponsor interactions & Change Order negotiations to optimise project revenue generation on assigned projects while maintaining positive CRO-Sponsor relationships.
  • Work with SCOM to prioritise assigned workload appropriately to meet agreed timelines, identify risks and manage the escalation process.
  • Maintain and update the Change Order Log on an ongoing basis to ensure accurate records of all assigned projects’ out of scope activities to support the centralised reporting of change order status to meet business needs.
  • Work with Head of COM and SCOM to ensure that processes and systems designed to support Change Order Management and thereby the business are both fit for purpose and are adhered to, and assist in identifying process improvements on an ongoing basis to facilitate this.


  • Degree or equivalent level qualification in any discipline
  • Able to demonstrate competency in budget development and revenue analysis
  • Previous experience/knowledge of CRO pricing tools and strategies
  • Understanding of clinical development process, services provided and associated terminology
  • Previous experience in managing project out of scope processes and contract negotiations
  • Ability to manage complex processes, with a focus on ‘right first time’ and ‘on-time delivery’
  • Ability to appropriately prioritise workload to meet agreed timelines

  • Clinical research or business-related degree
  • Higher degree in life sciences or business-related qualification
  • Previous experience in Contract management/legal knowledge
  • Previous experience with managing CRO-sponsor relationships


Simbec-Orion is growing fast. To keep up with demand, we’re looking for the best people, from all areas of clinical development, to join our team.

We’re dedicated to bringing the latest advances in science to market. Exposure to truly innovative new drugs in patient populations with serious unmet medical needs is what drives our company - and your reason to be a part of it.

With experts from all disciplines under the same roof, you’ll work alongside some of the industry’s best. So if you’d like to further your career within challenging therapeutic areas in rare disease, oncology, or at our clinical pharmacology site, or laboratory services. We’re waiting to hear from you.