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BIOTECHNOLOGY - TEAM LEADER OF PROTEIN TECHNOLOGIES

Employer
Barrington James
Location
Switzerland (CH)
Salary
UP TO 130,000
Start date
20 Sep 2019
Closing date
20 Oct 2019

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Job Details

ROLE OVERVIEW

to focus on protein production for the discovery of antibodies and bi/multispecific antibodies. We invite a motivated, interactive, and creative individual who possesses substantial experience in mammalian cell culture, antibody expression and purification, antibody characterization and a strong interest in the field. Experienced and effective leader with expertise in leveraging mammalian antibody expression platforms to facilitate discovery research. You will lead and mentor principal scientists, research officers and associates.

 

SPECIFIC REQUIREMENTS:

 Establish a highly functioning protein technology group

 Lead protein production group to generate antigens and antibodies to support discovery research and support projects

 Utilize and develop novel technologies/methodologies to express and purify antigens including difficult to express proteins

 Implement and supervise protein purification automation

 Implement and supervise early protein analytics of innovative antibody formats

 Guide scientists and team to address complex processes and transition leads for industrialization

 Accomplish goals under project team timelines

 Interface with multiple discovery project and matrix teams across the organization

 Effectively manage projects and resources to maximize progress

 Effectively communicate research progress and opportunities to senior management and scientific advisors

 Publish research in high-tier journals and present team’s work at international meetings

 Build a culture that embraces scientific excellence, continuous learning, and increasing team’s ability to deliver novel drug candidates

 

REQUIREMENTS:

 Ph.D. in Biochemistry, Structural/Molecular Biology, or related field with 6-8 years of relevant industrial experience in a similar role

 Extensive experience in leading a core group of scientists to make high quality proteins for in vitro and in vivo testing

 Strong knowledge and experience in making proteins and antibodies from multiple species

 Strong expertise in mammalian cell expression (HEK and CHO) and bispecific technologies is required

 Strong hands-on experience with multiple expression systems/formats (mammalian, insect, yeast, and E. coli) and purification media (affinity, ion-exchange, hydrophobic, size-exclusion chromatography) and automation is required

 Demonstrated ability to make complex antigens like multi-transmembrane receptors, oligomers, and difficult to express and purify proteins

 Demonstrated ability to generate proteins for x-ray crystallography and cryo-EM

 Experience in generating cell-lines (electroporation, viral transduction, transposons etc.) is also required

 Experience in evaluating antibody liabilities and formulations is highly desirable

 Excellent hands-on knowledge of antibody analytical methods

 Excellent time management and organizational skills

 Demonstrated ability to work in a multidisciplinary biologics discovery team

 Superior Project Management/Project Leadership skills

 Ability to manage multiple priorities and align internal and external stakeholders

 Excellent written and oral skills are necessary

Company

We’re great at what we do. A collection of the worlds finest Life Science recruiters working for the worlds best Life Science consultancy.

Originally, a purely contingency and contract recruiter, focused in the UK, Barrington James is now a sophisticated, highly effective provider of human resources solutions up to full RPO, partnering the pharma, medical devices, and healthcare industries right across the globe.

Company info
Website
Telephone
01293 776644
Location
Victoria House
Consort Way
Horley
Surrey
RH6 7AF
GB

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