PRINCIPAL SCIENTIST, PROTEIN TECHNOLOGIES - BIOTECH

Expiring today

Location
Switzerland (CH)
Salary
UP TO 130,000
Posted
19 Sep 2019
Closes
19 Oct 2019
Ref
CRBG - PSPS
Hours
Full Time
Contract Type
Permanent
Experience Level
Management

REQUIREMENTS:

 Ph.D. in Biochemistry, Structural/Molecular Biology, or related field with 6-8 years of relevant industrial experience in a similar role

 Extensive experience in leading a core group of scientists to make high quality proteins for in vitro and in vivo testing

 Strong knowledge and experience in making proteins and antibodies from multiple species

 Strong expertise in mammalian cell expression (HEK and CHO) and bispecific technologies is required

 Strong hands-on experience with multiple expression systems/formats (mammalian, insect, yeast, and E. coli) and purification media (affinity, ion-exchange, hydrophobic, size-exclusion chromatography) and automation is required

 Demonstrated ability to make complex antigens like multi-transmembrane receptors, oligomers, and difficult to express and purify proteins

 Demonstrated ability to generate proteins for x-ray crystallography and cryo-EM

 Experience in generating cell-lines (electroporation, viral transduction, transposons etc.) is also required

 Experience in evaluating antibody liabilities and formulations is highly desirable

 Excellent hands-on knowledge of antibody analytical methods

 Excellent time management and organizational skills

 Demonstrated ability to work in a multidisciplinary biologics discovery team

 Superior Project Management/Project Leadership skills

 Ability to manage multiple priorities and align internal and external stakeholders

 Excellent written and oral skills are necessary

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