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Principal Scientist/Senior Scientist Biomarker Immunoassay

Employer
UCB S.A
Location
Slough, Berkshire (GB)
Salary
Competitive salary + benefits package
Start date
22 Jul 2019
Closing date
21 Aug 2019

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Job Details

At UCB everything we do starts with a simple question: “How will this make a difference to the lives of people living with severe diseases?” We do that by connecting with patients and their families around the world living with the physical and social burdens of severe disease of the immune system and the central nervous system. Those connections offer new perspectives, drive innovation, and offer the hope of a new generation of therapies that will help to transform lives.

Role Overview   

The Translational Biomarkers and Bioanalysis group is positioned within the function of Development Sciences, which as a division provides strategy and support in integrated pharmacokinetics/pharmacodynamics and DMPK, bioanalysis, immunogenicity, safety, pathology, and regulatory activities throughout the lifespan of projects, from target identification through to clinical studies. The Translational Biomarkers and Bioanalysis department operate and collaborate closely with colleagues in Development Sciences and across the organization to support bioanalysis and biomarker activities.

The Biomarker Immunoassay Group within Translational Biomarkers and Bioanalysis is looking for high caliber, self-motivated, lab-based candidates with a strong scientific background, good written and verbal communication skills and who can multi-task effectively and adapt to meet the demands of a fast-paced matrix-team environment.

The role is based in Slough, UK.


Essential Requirements

You will employ your expertise for the development of complex biomarker assays for measuring analytes in biofluids and tissue samples exploring diverse approaches to ensure delivery of high-quality fit-for-purpose assays

  • Using in-house developed or commercially available immunoassays to measure the levels of biomarkers and biologic drug candidates
  • Assessment of novel biomarkers to ensure right dose, right molecule and right patient population within future clinical trials
  • Where appropriate, characterize antibodies, conduct reagent evaluation and perform reagent qualification assays
  • Provide in-depth knowledge of assay development and troubleshoot technical challenges across multiple platforms
  • Provide the appropriate levels of assay quality to ensure fit for purpose use
  • Work within the Bioanalytical area to optimize experimental design, troubleshooting, sample analysis, data interpretation and report generation
  • You will have in-depth knowledge of bioanalytical tools to provide scientific and technical input to Project teams, Biomarker teams and Development Sciences teams
  • Liaise with statistics and bioinformaticians to ensure optimum design of experiments
  • Ensure compliance with all health and safety regulations
  • Work within collaborations with external partners, academic institutions, CROs and consultants as required
  • Maintain an awareness of new / emerging techniques and tools relevant to the field
  • Represent and align with the objectives of Development Sciences internally and externally in matters relevant to biomarkers and bioanalysis

Essential Requirements

  • The Applicant should have minimum of MSc (or equivalent) in a biological discipline
  • Extensive expertise with development of ligand binding assays/immunoassays
  • Experience of immunoassays, including but not limited to ELISA, MSD, high sensitivity platforms such as Singulex, Simoa/Quanterix.
  • Proven track record of developing novel fit for purpose biomarker assays from first principles for pre-clinical and clinical assessments
  • Experience with the appropriate biomarker assay validation towards supporting clinical assessments and knowledge of the latest regulatory standards
  • Clear grasp of context of use (linking assay requirements to the usage of the data generated)
  • A keen understanding of the impact of biological and assay variability for fit for purpose biomarker assay development and data interpretation and proven expertise in delivery
  • Demonstrated ability to work effectively in a dynamic laboratory environment to project timelines with minimal supervision
  • An ability to work in a matrix and communicate clearly to colleagues and project scientists, able to discuss ideas, provide constructive challenge and useful feedback
  • Adaptable to changing project and organizational priorities and consistently aligned with departmental needs

Desired Skills & Experience

Previous experience of working in a pharmaceutical drug discovery and assay development environment is highly desirable.

  • Experience working with a wide range of internal stakeholders including Therapeutic Area, Non-Clinical Safety, DMPK, Translational Medicine, Clinical Pharmacologists, Clinical operations and Quality Assurance colleagues
  • The analysis of pharmacokinetic and pharmacodynamic endpoints
  • Experience of working with electronic lab notebooks
  • Knowledge of statistical tools for the analysis of assays

We can offer you a competitive salary and benefits package.

Please ensure all applications are submitted by Fri 26th July 2019.

Company

A global biopharma company, focusing on neurology and immunology.

Our business is strong. Total revenue grew to €4.9 billion in 2019. We are more than 7,600 people in all four corners of the globe, inspired by patients and driven by science.

Our vision

UCB’s ambition is to transform the lives of people living with severe diseases. We focus on neurology and immunology disorders – putting patients at the center of our world. We are Inspired by Patients. Driven by Science.

UCB is continuously working to advance science and embrace new knowledge. We are leveraging scientific advances and skills in areas such as genetics, biomarkers and human biology. Patients inspire us to bring them value through cutting-edge science, innovative drugs, and practical solutions – so that they and their carers can get on with their lives.

Our strategy

We recognise that radical changes are taking place in the eco-system of care and that we need to evolve accordingly to deliver on our vision. The key element of our evolution is to focus on the delivery of increased patient value.

There is no such thing as an “average patient”. We want to use all the tools, channels and scientific advances at our disposal to develop a better understanding of the various expressions of a disease and embed the real needs of specific patient populations in our science and innovation process.

That is why we support patient groups who provide valuable services to patient communities and understand what matters to people living with severe diseases.

We believe in partnership. Our scientists collaborate with leading researchers from academia and industry to advance science and deliver the solutions patients need. Our open approach to innovation equips us to meet today’s biggest healthcare challenges.

Company info
Website
Telephone
+32 2 559 92 64
Location
Allée de la Recherche,
60
1070
Brussels
BE

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