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Principal Scientist, Analytical Development Group

Employer
Oxford BioMedica (UK) Limited
Location
Oxford, Oxfordshire (GB)
Salary
Competitive
Start date
14 Feb 2019
Closing date
8 Mar 2019

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Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

Oxford BioMedica’s Analytical Development Group (ADG) is seeking to strengthen its team by recruiting an experienced scientist who can contribute to providing first rate analytical development for external partnerships and for the company’s portfolio of cell and gene therapies. The group functions in a multi-disciplined innovative environment whilst also adhering to internal and external quality systems. ADG is part of the Research Department but works closely with manufacturing, clinical and analytical services at all stages of development. The team is responsible for assay development and subsequent validation to support the GMP manufacturing process and early phase development.

A highly motivated principal scientist is sought to support and provide expertise in the Analytical Development Group. The successful candidate will be expected to:

Key responsibilities and accountabilities:

  • Have responsibility for the research, development and implementation of new and existing assays to support internal and external cell and gene therapies programmes
  • Support the development of Oxford BioMedica’s pipeline and work closely with Project Management
  • Line management of junior scientists
  • Troubleshoot assay performance issues as and when required
  • Drafting and preparation of standard operating procedures for new assays
  • Assist in the scheduling, management and execution of the ADG to deliver programs of work
  • Act as project manager for validation, qualification and transfer studies both internally and with external partnerships.
  • Training members of the Analytical Services Group (ASG) to perform newly developed and validated assays

Key skills and requirements: 

  • Previous experience with assay development and validation in an industrial setting
  • Experience with qPCR and protein analysis
  • An understanding of lentiviral vectors and gene therapy preferred
  • Experience of line management
  • Use of statistics as applied to assay validation
  • The ability to train others in the conduct of analytical techniques

Person Specification:

  • BSc Degree in Life Sciences/Science/Analytical Science
  • Demonstrated ability to work independently as well as in a team
  • Good written and verbal communication skills
  • Ability to undertake projects to agreed timelines and adapt to rapid changes in project priorities

No agencies please

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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