Clinical Professionals Ltd

Group Leader - Fermentation

09 Jan 2019
14 Feb 2019
R & D , Scientific

Our client's class-leading platform enables precise and large-scale identification of gut bacteria associated with health or disease, enabling the design of novel medicines and biomarkers based on live bacteria. In just two years, the company has established itself as an industry leader, having won four awards and recently signed a $534m strategic multi-year deal with a US based biotech to discover novel biomarkers, targets and medicines in inflammatory bowel disease. The company has a pipeline of live bacterial products for C. difficile, ulcerative colitis and cancer which will be progressed to the clinic.

Our client is now seeking a driven, organised and proactive individual to lead the Fermentation group in the Preclinical Development Team. This is an exciting opportunity for an enthusiastic scientist to play a key role in building a young biotech company and to contribute to the development of a new class of medicines.

Role and Responsibilities
The role will contribute to the preclinical development of novel medicines comprising a consortium of live bacteria delivered orally to the intestinal tract. The first programmes are in C. difficile infection, currently in preclinical development, and in ulcerative colitis. The successful candidate will be responsible for in-house fermentation of multiple anaerobic gut bacteria that comprise the medicine, characterising and optimising their growth and providing support for upstream and downstream method development and optimisation.

The major areas of responsibility are:
Leading a small team, develop fermentation processes to produce live bacterial therapeutics comprising multiple bacterial strains
Performing anaerobic fermentation of bacteria from microtiter plates to small fermenters
Maintaining an awareness of latest technologies and equipment for incorporation into company labs
Optimising media for growth of physiologically diverse bacteria
Equipment maintenance
Ensuring detailed records of experiments are kept, suitable for supporting regulatory filings.
Supporting process transfer to CDMOs

Candidate Specifications:
Essential requirements for this post include:
PhD in relevant discipline eg: Microbiology or Bioprocess Engineering with focus on fermentation and cell harvest or experience in equivalent closely-related discipline
5 years post-doctoral experience in a bioprocess development environment utilising fermentation technology
Experience of optimising biotech processes and methodologies that can be applied to microbiome research.
Ability to rigorously plan and accurately document research activities

Desirable requirements for this post include:
Experience of leading small teams
Experience of using Design of Experiments (DOE)
Expertise in handling and culturing anaerobic bacteria
Experience of developing processes for subsequent application in GMP manufacture
Experience of process technology transfer to external companies
Experience of freeze drying of bacteria
Experience of biobanking and the maintenance of culture collections

The following personal attributes are essential:
A high level of leadership and initiative.
A team worker with willingness to contribute flexibly as required
Excellent communication and interpersonal skills
Candidates must be legally entitled to work in the UK

If this role sounds like it could be of interest to you, or you would like to find out more about the position, client or process, please contact Matt Walsh on 0207 822 1710 or email an up to date version of your CV to

If however, you do not feel that this is the right role for you, please forward these details on as we do have a generous referral scheme in place. Please note, due to the high volume of applications, if you do not receive a response within 48 hours, your application has not been successful on this occasion.

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