Clinical Professionals Ltd

Group Leader - Fermentation

Location
Cambridgeshire
Salary
Competitive
Posted
20 Sep 2018
Closes
09 Feb 2019
Ref
JO-1809-416607
Discipline
R & D

Our client, a ground-breaking Biopharmaceutical company based in Cambridge, are seeking a driven, organised and proactive individual to lead their Fermentation group in the Preclinical Development Team. This is an exciting opportunity for an enthusiastic scientist to play a key role in building a new biotech company and to contribute to the development of a new class of medicines.

Role and Responsibilities
The role will contribute to the preclinical development of novel medicines comprising a consortium of live bacteria delivered orally to the intestinal tract. The first programmes are in C.difficile infection, currently in preclinical development, and in ulcerative colitis. The successful candidate will be responsible for in-house fermentation of multiple anaerobic gut bacteria that comprise the medicine, characterising and optimising their growth and providing support for upstream and downstream method development and optimisation.

The major areas of responsibility are:
Develop fermentation processes to produce live bacterial therapeutics comprising multiple bacterial strains
Anaerobic fermentation of bacteria from microtiter plates to small fermenters
Maintain an awareness of latest technologies and equipment for incorporation into company labs
Optimise media for growth of physiologically diverse bacteria
Equipment maintenance
Keeping detailed records of experiments

Candidate Specifications:
Essential requirements for this post include:
PhD in Microbiology or Bioprocess Engineering with focus on fermentation and cell harvest or experience in equivalent closely-related discipline
5 years post-doctoral industrial experience in a bioprocess development environment utilising fermentation technology
Experienced in using Design of Experiments (DOE)
Experienced in optimising biotech processes and methodologies relevant to microbiome research.
Ability to rigorously plan and accurately document research activities

Desirable requirements for this post include:
Management experience leading small teams
Expertise in handling and culturing anaerobic bacteria
Experience of developing processes for subsequent application in GMP manufacture
Experience of process technology transfer to external companies
Experience in freeze drying of bacteria
Experience in biobanking and the maintenance of culture collections

The following personal attributes are essential:
A high level of leadership and initiative.
A team worker with willingness to contribute flexibly as required
Excellent communication and interpersonal skills
Candidates must be legally entitled to work in the UK

If this role sounds like it could be of interest to you, or you would like to find out more about the position, client or process, please contact Ed Thomas on 0207 822 1710 or email an up to date version of your CV to edward@clinicalprofessionals.co.uk

If however, you do not feel that this is the right role for you, please forward these details on as we do have a generous referral scheme in place. Please note, due to the high volume of applications, if you do not receive a response within 48 hours, your application has not been successful on this occasion.

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