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Target Identification and Validation Associate Scientist

Abingdon, England, Oxfordshire / England, Oxfordshire, Oxford
GBP27000 - GBP30000 per year
Start date
23 May 2024
Closing date
22 Jun 2024

View more

R & D , Biochemistry, Biotechnology
Full Time
Contract Type
Experience Level

Job Details

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.

We are looking for a collaborative and enthusiastic junior scientist to join our Target Identification and Validation team. We are discovering and validating novel therapeutic targets for TCR-based immunotherapy drugs (ImmTAC/ImmTAI) across different therapeutic areas.

This is a very exciting opportunity for a passionate and pro-active individual that is keen to learn, innovate, collaborate and contribute to successes of a highly performing Target Validation Team, within one of the leading biotech companies.

Key responsibilities

* Analyse expression of cancer/autoimmune targets on mRNA and protein level
* Assess target single cell distribution across various cancer and normal tissues
* Assess associations of target expression to key molecular subtypes
* Collaborate cross-functionally to develop optimal disease models for ImmTAC testing
* Analyse and report experimental results verbally and in writing

Essential skills: qPCR, Immunohistochemistry (IHC), In situ hybridization (ISH), cell culture

Desirable skills: Flow cytometry/FACS


* Essential: MSc in Cancer biology/Immunology or equivalent experience within a drug discovery industrial environment


We are a pioneering, commercial-stage T cell receptor biotechnology company working to develop and commercialize a new generation of transformative medicines to address unmet needs in cancer, infectious and autoimmune diseases.

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