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(Senior) Scientist, Oligonucleotide Chemistry

Proclinical Staffing
Massachusetts, Boston, USA
Highly Competitive Salary
Start date
20 Jan 2023
Closing date
1 Feb 2023

View more

R & D , Chemistry
Full Time
Contract Type
Experience Level
Experienced (non-manager)
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Job Details

Proclinical is currently recruiting for a (Senior) Scientist in Oligonucleotide Chemistry to join a newly founded Biotech in Boston, MA. The candidate will perform synthesis and purification of modified oligonucleotides (ASO, siRNA) for our drug discovery programs. Successful candidates will have significant experience with solid phase chemical synthesis (oligonucleotide or peptide), conjugation, HPLC purification, and LC-MS analysis, preferably with oligonucleotides.

Job Responsibilities:

  • Automated synthesis, cleavage, deprotection, purification, analysis and packaging of oligonucleotides, including heavily modified oligonucleotides.
  • Monitoring, troubleshooting, maintenance, repair equipment or engage repair services of the oligonucleotide synthesizer, HPLC machines and benchtop equipment to ensure consistent and reliable oligonucleotide production.
  • Critical evaluation and optimization of the processes to improve synthesis yield, purity and timelines for production of modified oligonucleotides
  • Manage ordering and organization of chemicals and supplies necessary for oligonucleotide synthesis
  • Curate and maintain the inventory of synthesized oligonucleotides

Skills and Requirements:

  • PhD in Chemistry, Chemical/Process Engineering or Biochemistry
  • 2-5 years' experience in an industry setting, self-motivated with the ability to work in a fast-paced environment
  • Strong analytical skills
  • Strong problem-solving skills for developing creative, innovative solutions, and meeting project objectives.
  • Extensive experience in driving and supporting external teams at CRO's.
  • Proven track record of scientific contributions to projects, including co-inventorship on patents.
  • (Co)-authorship on publications and presentations is required.
  • Strong interpersonal skills.
  • Scientific creativity, independent thought and decision-making ability.
  • Outstanding written, verbal and presentations skills.
  • Exceptional problem-solving skills.

If you are having difficulty in applying or if you have any questions, please contact Max Robinson at 857-362-9542 or

Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.

Proclinical Staffing is an equal opportunity employer.



At ProClinical we have one aim: to support life science companies in the many challenges they face while combatting unmet medical need worldwide.

Ageing populations, rare diseases, epidemics and the millions of patients without access to medication are just a few of the pressing issues that life science companies contend with. The industry is under increasing pressure to develop new and innovative ways to save and improve patients’ lives. 

ProClinical’s mission is to support their work by connecting life science companies with the highly skilled professionals they need to continue innovating. 

Internal recruitment and HR teams often struggle to continuously source skilled, experienced professionals to fill highly-specialised and niche roles. ProClinical combines a deep understanding of the industry with extensive candidate networks to provide both a technical and cultural fit for our life science partners.


Find Us
0800 988 4437
Eldon House
Eldon Street
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