Scientist I, Downstream Process Development

Employer
Novavax
Location
Gaithersburg, Maryland, United States
Salary
Competitive
Start date
19 Nov 2022
Closing date
19 Dec 2022

View more

Discipline
Manufacturing, Process
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)
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Job Details

If you find science, speed, and success exhilarating, you have come to the right place.

Novavax, Inc (Nasdaq:NVAX) is a biotechnology company that creates transformational vaccines that address some of the world’s most pressing infectious diseases. We have more than a decade of experience contending with some of the world’s most devastating diseases, including COVID-19, seasonal influenza, RSV, Ebola, MERS, and SARS. Hard-won lessons and significant advances illustrate that our proven technology has tremendous potential to make a substantial contribution to public health worldwide.

Our scientists are committed to developing vaccine candidates for some of the world’s toughest viral threats by utilizing the power of our innovative recombinant nanoparticle vaccine platform. Our vaccine technology combines the power and speed of genetic engineering with the immunogenicity enhancing properties of our Matrix-M™ adjuvant to efficiently produce highly immunogenic particles targeting some of the most pressing viral infectious diseases.

Novavax, Inc. is headquartered in Gaithersburg, Maryland with additional facilities in Uppsala, Sweden and Bohumil, Czech Republic.

Summary of the Position :

Novavax is seeking a Scientist to join our Downstream Process Development group in Gaithersburg, MD. Qualified individuals will play a role in downstream process development and process characterization activities, new technology evaluation, and technical support of cGMP manufacturing for proteins, nanoparticles, and virus-like particle (VLP) based vaccines. The candidate will ensure scientifically sound experimental design, data analysis, and reporting. The candidate will be responsible for drafting technical development reports summarizing critical data. The candidate is expected to be highly self-motivated, well organized, and an innovative thinker focused on execution with a sense of urgency. This position will report to the Senior Director, Downstream Process Development.

Responsibilities include but are not limited to :
  • Perform hands on work in a downstream purification lab, specifically column chromatography and filtration operations for vaccine production, process development, process characterization, and scale up.
  • Develop and optimize early-stage processes and complete process characterization studies.
  • Perform lab-scale experiments to identify root-causes, support process changes, generate, and/or resolve manufacturing non-conformances.
  • Perform Design of Experiment (DOE) studies to develop or optimize processes to ensure a phase-appropriate, consistent, high-yielding, and scalable downstream process.
  • Routinely present experimental findings to cross-functional project teams and management.
  • Write technical reports utilizing sound scientific reasoning and interpretation of the available data. Generated documents will include process flow diagrams, process descriptions, and technical support studies.
  • Perform analytical assays, as needed.
  • Collaborate and coordinate with colleagues from Discovery, Process Sciences, Upstream Development, Formulation Development, and Analytical Development teams.
  • Train staff on new process and technologies, as needed.
  • This position is expected to be mainly hands on in the laboratory.

Minimum Requirements :
  • BA/BS in Bio/Chem Engineering, Biology, Chemistry, Pharmaceutical Science, Biochemistry, biophysics, Molecular Biology, Life Sciences, vaccine development, or a related scientific discipline with 5 plus years of experience, or MS degree with 2 plus years of experience in pharmaceutical or biotech companies.
  • A thorough understanding and working knowledge of the principles of purification and filtration processes is essential, with solid hands-on downstream process experience with chromatography systems, such as AKTA, and tangential flow (UFDF) filtration is required.
  • Experience with or working knowledge of analytical assays, such as gel electrophoresis, Western Blotting, ELISA, etc. is required.
  • Excellent record keeping abilities to adequately record, analyze and document data generated in support of regulatory requirements are essential.
  • Ability to think critically, demonstrate troubleshooting and problem-solving skills.
  • Excellent interpersonal, verbal and written communication skills are essential.
  • Self-motivated with a strong sense of ownership in areas of responsibility and willingness to accept temporary responsibilities outside of initial job description.
  • Ability to work and collaborate in cross functional teams (research, development, and manufacturing) in a fast pace and dynamic team setting with a sense of urgency.
  • High energy level and a positive outlook coupled with the requisite “can do” attitude and a willingness to do what it takes to achieve personal and organizational goals and overcome obstacles.

Preferred Qualifications :
  • Direct experience with virus-derived recombinant products and/or viral particles and cell harvest and clarification techniques (centrifugation, filtration, etc.) is a plus.
  • Practical demonstration of the use of statistical design of experiments and statistical analysis is a plus.

Novavax offers a base salary, annual bonus, equity grants, professional career development/growth opportunities, and a comprehensive benefits package including medical, dental, vision, Rx, STD, LTD, Life, Optional Life, 401(k) plan.

Equal Opportunity Employer/Veterans/Disabled

Novavax is an equal employment opportunity employer. Employment and advancement opportunities are available to all individuals on an at-will basis, regardless of their race, color, national origin, religion, ancestry, citizenship status, military or veteran status, sex, sexual orientation, gender identity or expression, age, marital status, family responsibilities, pregnancy, disability, genetic information, protective hairstyle, or any other characteristic protected by applicable federal, state, or local law.

Except where prohibited by applicable state law, this position requires that you be fully vaccinated against COVID-19 unless you need a reasonable accommodation or qualify for an exemption.

#LI-SB

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities

The contractor will not discharge or in any other manner discriminate against employees or applicants because they have inquired about, discussed, or disclosed their own pay or the pay of another employee or applicant. However, employees who have access to the compensation information of other employees or applicants as a part of their essential job functions cannot disclose the pay of other employees or applicants to individuals who do not otherwise have access to compensation information, unless the disclosure is (a) in response to a formal complaint or charge, (b) in furtherance of an investigation, proceeding, hearing, or action, including an investigation conducted by the employer, or (c) consistent with the contractor’s legal duty to furnish information. 41 CFR 60-1.35(c)

Company

We are a biotechnology company committed to help address serious infectious disease globally through the discovery, development, and delivery of innovative vaccines to patients around the world.

 

Our mission

We never rest in our quest to protect the health of people everywhere.

Novavax is here to make a difference. We’re a biotech company focused solely on developing life-saving vaccines to fight infectious diseases.

What sets us apart? Solid science tested by decades of research. Vaccines developed from trusted technology that are both safe and efficacious.

And a global network that will help ensure our vaccines reach everyone who needs them.

Find Us
Website
Mini-site
Novavax
Location
21 Firstfield Rd
Gaithersburg
MD
20878
US

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