Associate Scientist to Principal Scientist, Biology
- Employer
- Proclinical Staffing
- Location
- Pennsylvania, USA, Philadelphia
- Salary
- Negotiable
- Start date
- 5 Aug 2022
- Closing date
- 19 Aug 2022
View more
- Discipline
- R & D , Scientific
- Hours
- Full Time
- Contract Type
- Permanent
- Experience Level
- Experienced (non-manager)
Job Details
Proclinical are recruiting an individual from Associate Scientist to Principal Scientist level to join a biology team for an exciting biotech organisation. This role is on a permanent basis and is located in Philadelphia, PA. This client is focused on discovery and development of disease-modifying therapies by harnessing natural protein homeostasis processes.
Responsibilities:
This is a lab-based role in the biology department, reporting to Director of Biology.
- Apply state-of-the-art drug discovery approaches as part of a multi-disciplinary team.
- Lead the design, development, and execution of innovative cell-based assays to support progression of programs through all phases of drug discovery.
- Analyse, interpret, summarise, and present research findings at project team meetings, leadership meetings, and external scientific conferences
- Ensure data quality and data integrity.
- Lead and contribute to target assessment endeavours.
Qualifications:
Required
- M.S./B.S. with 8+ years of drug discovery experience in biotech and/or pharmaceutical companies.
- Demonstrated ability to independently design, conduct, and analyse complex in vitro preclinical studies.
- Experience in novel target discovery and validation, including contributing to multiple projects simultaneously.
- Proficient in cell biology techniques such as mammalian cell culture, Western blotting, qPCR, siRNA/CRISPR knockdown, MSD/ELISA and flow cytometry.
- Ability to mentor/guide junior scientists in the lab.
- Ability to use routine laboratory software such as XLFit, GraphPad Prism, ELN etc.
- Strong problem-solving ability in a science-driven organisation.
- Ability to work independently, effectively collaborate and help lead in a team environment.
- Ability to critically analyse, interpret and present data in a publication ready format with recommendations for next steps.
Desired
- Knowledge in small molecule protein degradation via proteosome system and understanding in biology of ubiquitin-proteasome system (UPS), heterobifunctional degraders or molecular glues.
- Assay development expertise in protein degradation related cell-based assays (e.g., in-cell western or HiBit assays).
- Experience with high-throughput cell-based assays, such as plate-reader based activity assays, reporter assays, high content imaging and assay automation.
- Experience with developing small molecule preclinical data packages to support IND-readiness for first-in-human studies.
If you are having difficulty in applying or if you have any questions, please contact Danielle Bahnasy at (+1) 646-868-5142.
Proclinical is a specialist employment agency and recruitment business, providing job opportunities within major pharmaceutical, biopharmaceutical, biotechnology and medical device companies.
Proclinical Staffing is an equal opportunity employer.
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Company
At ProClinical we have one aim: to support life science companies in the many challenges they face while combatting unmet medical need worldwide.
Ageing populations, rare diseases, epidemics and the millions of patients without access to medication are just a few of the pressing issues that life science companies contend with. The industry is under increasing pressure to develop new and innovative ways to save and improve patients’ lives.
ProClinical’s mission is to support their work by connecting life science companies with the highly skilled professionals they need to continue innovating.
Internal recruitment and HR teams often struggle to continuously source skilled, experienced professionals to fill highly-specialised and niche roles. ProClinical combines a deep understanding of the industry with extensive candidate networks to provide both a technical and cultural fit for our life science partners.
- Website
- https://www.proclinical.com/
- Telephone
- 0800 988 4437
- Location
-
Eldon House
Eldon Street
London
EC2M 7LS
United Kingdom
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