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Senior Scientist ASG

Employer
Oxford BioMedica (UK) Limited
Location
Oxford
Salary
Competitive
Start date
16 May 2022
Closing date
15 Jun 2022

View more

Discipline
HEOR, Analyst, R & D , Biochemistry
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

Job description:
 

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

 

 

Oxford BioMedica’s Analytical Services Group supports the development of products through analytical testing to facilitate manufacturing and process development, ensuring appropriate quality controls and use of analytics.

 

 

We are currently recruiting for a Senior HPLC Scientist to join the team.  The purpose of this role is to work within a small team of Scientists responsible for ensuring that reported QC release and stability results are robust, accurate and scientifically sound

 

Your responsibilities in this role would be:

  • Transfer of new assays from ADG (Analytical Development Group) to ASG, ensuring that the assays are scientifically sound and fit-for-use in GMP
  • Developing, validating and conducting all UPLC/HPLC analytical methods
  • Responsible for the set up and maintenance of a HPLC laboratory area and HPLC equipment.
  • Responsible for the training and development of scientists in HPLC analysis
  • Responsible for ensuring compliance of the CDS (cheomatography data system) in conjunction with the Analytical Services Administrator
  • Implementation of updates to GMP assays used in ASG following development work or validation
  • Management of analytical spreadsheets required for the calculation of results
  • Management and justification of assay acceptance criteria
  • Support the management of in-house control materials, including qualification studies to ensure fit-for-use
  • Monitoring of assay performance and investigation of any observed trends
  • Contribute to and/or lead thorough and timely investigation of invalid assays
  • Contribute to and/or lead thorough and timely investigation of OOS, OOE and OOT events
  • Contribute to and/or lead trouble-shooting into HPLC related assay problems inhibiting the reporting of results
  • Communicate with clients regarding product related HPLC analytics

 

To be successful in this role, you will have the following skills and experience:

 

  • Minimum BSc Degree programme level (or equivalent) with relevant experience in UPLC/HPLC
  • Proven technical analytical experience with particular emphasis on HPLC and UPLC within a GMP environment.
  • Working knowledge of assay development and/or validation
  • Ability to assess assays prior to transfer to ensure they are robust and scientifically sound
  • Use critical thinking skills to identify and solve assay-related problems
  • Apply appropriate acceptance criteria to assays and test samples to ensure robust and consistent assay performance
  • Use scientific understanding of assays to suggest continuous improvement activities
  • Understanding of basic statistical techniques for data analysis
  • Strong working knowledge of Microsoft Excel
  • Consistently ensure GMP compliance in all areas of work.
  • Strong knowledge and experience of working within a GMP environment
  • Experience of working with lentiviral vectors an advantage
  • Experience in qPCR Molecular Biology and protein chemistry would be an advantage
  • Working knowledge of JMP and Minitab an advantage

 

 

 

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

 

 

Collaborate. Contribute. Change lives

 

 

No agencies please

 

 

 


We offer:

 

 

 

We are a pioneering gene therapy business, and our mission is delivering life changing gene therapies to patients. We work together, motivated to make a difference, and so can you.

We are pioneers; no one else does what we do.

Gene therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells. It is transforming medicine as we know it, long term and potentially curative treatments for a wide range of diseases are now possible.

We are at the forefront of this exciting area. We have a strong reputation in gene therapy, with world leading expertise in lentiviral vectors. We have a leading, integrated platform of exclusive technologies to design, develop and bioprocess unique gene based medicines, both in house and with partners.

We drive credible science to realise incredible results.

Whether you’re motivated by the discovery and development of product candidates within Research, or by cutting edge tools and technologies including AI and automation of our contract development and manufacturing organisation, we can offer you a career like no other. We are excited about our future. Join us and change lives.

 

 

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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