Director of Protein Science

Hobson Prior are seeking a Director of Protein Science to join a pharmaceutical organisation who discover and develop cutting edge therapies that will make a difference in the lives of patients. This role will be on a permanent basis and will be located in Basel.

Please note that to be considered for this role you must have the right to work in this location.

Key Responsibilities:

• Manage and continue to build the team for recombinant protein expression, purifications and characterization for supporting the development of next-generation protein therapies.
• Strong understanding and experimental background with demonstrated expertise in recombinant protein expression in E. Coli, mammalian and insect cells.
• Ensure development of robust and high-yielding expression and purification workflows for generating a small library of recombinant proteins for R&D, pre-clinical development.
• Ensure development of robust protein refolding, purification and characterization workflows in small and large scale.
• Ensure development of pre-formulation and stability assessments of lead, development candidates using state-of-the art biologics characterization and QC methods.
• Lead and oversee outsourcing and tech. transfer of protocols and production processes for scale-up and complete characterization to CRO's and CMO's.
• Act as liaison between the R&D and CMC team for developability assessment and for smooth transfer of upstream and downstream processes including analytical testing for development.
• Contribute to research strategy by advancing our portfolio in close collaboration with the CTO, CSO and group leaders in discovery and preclinical research.
• Inception and progression of current and future projects up to the identification of novel development candidates and IND.
• Provide scientific direction and support to project teams.
• Establish and manage external partnerships with CROs, consultants, academic collaborators and other partners.
• Supervise and mentor scientists and junior staff members.

Requirements:

• PhD and / or Post-doctoral training in biochemistry, molecular biology or related field and a minimum of 8 years of experience in pharmaceutical/biotechnology industry.
• Advanced understanding of R&D, preclinical research and drug development as well as regulatory process.
• Strong working knowledge of recombinant protein expression and characterization with an emphasis on expression of cytokines; experience with immunocytokines and nonstandard biologics formats (ADC, bispecific etc.) is a plus.
• Detailed understanding of protein refolding, recombinant expression and purification of lead and development drug candidates.
• Clear track record of successful discovery and progression of projects from discovery to IND
• Proven ability to foster scientific excellence and to guide strategic decisions in a data driven and solutions-oriented manner.
• Proven history of team leadership in an industry setting.
• Independence with proven ability to work in a cross-functional and collaborative environment.

Apply now:

If you are interested in learning more or applying to this exciting opportunity then please click "Apply" and upload a copy of your CV. Alternatively, for further details or to talk directly to a life sciences recruitment specialist directly, please select "Contact me" at the top of this page.

Hobson Prior is a leading life sciences recruiter focused on finding exceptional people and matching them with the finest positions across the globe. Hobson Prior is acting as an Employment Agency in relation to this vacancy.