Director, Process Research and Development

Employer
Oxford BioMedica (UK) Limited
Location
Oxford
Salary
Competitive
Start date
22 Nov 2021
Closing date
29 Nov 2021

View more

Discipline
R & D , Biotechnology
Hours
Full Time
Contract Type
Permanent
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Job Details

Job description:
 

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.

We are currently recruiting for a Director, Process Research and Development to join the team.  The purpose of this role is to lead and direct a new AAV production team within the Process Research and Development group and to be responsible for the development, optimisation and implementation of manufacturing processes suitable for the large-scale production of a variety of AAV based gene therapy vectors. The role will be to manage the effective performance of team(s) of scientists to meet requirements and to deliver both in-house and collaborative process development projects for a variety of viral vectors. A close working relationship with other groups within Process Research and Development as well as Platform Research and Manufacturing teams will be required.

 

Your responsibilities in this role would be:

  • The role will contribute to the cross-departmental development of an AAV manufacturing and development platform within Oxford Biomedica Lead and direct process development activities across upstream, downstream and analytical teams to support the manufacture of adeno-associated virus (AAV) based gene therapy vectors.
  • Accountable for the effective performance of the Process R&D Department, with tactical focus on the Department’s multiple varied complex activities and day-to-day operational management.
  • Support the development of a portfolio of gene-based therapies from early to late stage by providing expert input into project teams, directing development work, reviewing data, supporting regulatory, clinical and business development activities.
  • Identify and engage with external experts/academic groups in collaborative projects that will advance product development goals.
  • Maintain awareness of external technology and patent landscape and competitor process technology activity, and advise accordingly in order to ensure we are at the forefront of the relevant scientific fields.
  • Ensure focussed research that will benefit aspects of the product development pipeline i.e. product functionality and manufacture at GMP scale.
  • Proactively identify project risk and issues to the relevant internal stakeholders and external collaborators at an early stage.
  • Contribute to generation of new IP to secure future investments for the business.

 

To be successful in this role, you will have the following skills and experience:

  • Extensive knowledge and practical experience of bio-processes for the production, purification and analytical characterisation of adeno-associated virus (AAV) gene therapy vectors.
  • Extensive knowledge and practical experience of five or more of the following areas: gene therapy, virology, viral vectors, cell biology, pharmaceutical industry and process development of biopharmaceuticals, analytical techniques, high through-put technologies, and GxP / regulatory documentation.
  • From a deep scientific understanding be able to identify and disseminate the key advances within related scientific fields that affect current research activities.
  • Extensive understanding of the R&D activities across internal departments.
  • A good understanding of quality systems and regulatory requirements.
  • Understand the Health and Safety aspects of the work carried out in their department.
  • A strong track record in the research development/gene therapy/cell engineering/analytics/scale-up of biopharmaceuticals (Industrial experience and/or good publication record)
  • Management and leadership knowledge & experience within a fast-paced environment
  • Set individual objectives for direct reports and performs informal and formal performance reviews.
  • Strong motivator via coaching and actively promote the development and progression of team members through training and development
  • Lead cross-functional Project Teams to ensure they have the information and motivation to successfully deliver agreed projects
  • Lead quality improvements for PR&D Analytics activities, motivate and encourage a culture of continuous improvement to working practices, empower staff and encourage ownership
  • Build and maintain relationships with senior managers, internal partners/professionals to achieve business goals
  • Regularly presents the Department’s ongoing work to key stakeholders and collaborators (UK and International) utilising influencing skills to reach agreement on process development activities.

 

 

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

 

Collaborate. Contribute. Change lives.

 

 


We offer:

 

 

 

We are a pioneering gene therapy business, and our mission is delivering life changing gene therapies to patients. We work together, motivated to make a difference, and so can you.

We are pioneers; no one else does what we do.

Gene therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells. It is transforming medicine as we know it, long term and potentially curative treatments for a wide range of diseases are now possible.

We are at the forefront of this exciting area. We have a strong reputation in gene therapy, with world leading expertise in lentiviral vectors. We have a leading, integrated platform of exclusive technologies to design, develop and bioprocess unique gene based medicines, both in house and with partners.

We drive credible science to realise incredible results.

Whether you’re motivated by the discovery and development of product candidates within Research, or by cutting edge tools and technologies including AI and automation of our contract development and manufacturing organisation, we can offer you a career like no other. We are excited about our future. Join us and change lives.

 

 

Company

About us

We are a pioneering gene therapy business, and our mission is delivering life-changing gene therapies to patients.  We work together, motivated to make a difference, and so can you.

We are pioneers; no one else does what we do

Gene therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells. It is transforming medicine as we know it; long term and potentially curative treatments for a wide range of diseases are now possible.

We are at the forefront of this exciting area. We have a strong reputation in gene therapy, with world-leading expertise in lentiviral vectors. We have a leading, integrated platform of exclusive technologies to design, develop and bioprocess unique gene-based medicines, both in-house and with partners.

We drive credible science to realise incredible results.

Whether you’re motivated by the discovery and development of product candidates within Research, or by cutting edge tools and technologies including AI and automation of our contract development and manufacturing organisation, we can offer you a career like no other. We are excited about our future. Join us and change lives.

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Find Us
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
OX4 6LT
United Kingdom
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