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Principal Scientist, AAV - Cell Engineering

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire
Salary
Competitive
Start date
14 Oct 2021
Closing date
13 Nov 2021

View more

Discipline
R & D , Biotechnology, Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Management

Job Details

Job description:
 

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

We are currently recruiting for a Principal Scientist to lead the AAV research within the Cell Engineering Group (CEG) which is a group within the Platform Research Department. The purpose of the role is to evaluate new systems and cell lines for efficient AAV production.

Your responsibilities in this role would be:

  • Responsible for evaluating AAV vector kits and alternative cell lines to establish the best systems to implement for high titre AAV production
  • Evolve to evaluate the benefit of stable cell lines for the production of AAV
  • Line manage at least one direct report ensuring correct training/development of the team members in necessary techniques and general learning
  • This role will be predominantly lab based with some office time for managing the project and direct report(s)
  • Support/input into tech-transfer of AAV vector processes and/or feasibility studie
  • Report writing,
  • Support potential client programmes and the daily management of the AAV programme within CEG 

To be successful in this role, you will have the following skills and experience: 

  • PhD and post-doctoral experience in a directly relevant field (i.e. AAV vectors) in either academia or industry
  • A deep understanding and practical experience of AAV production and AAV vector quality attributes and analytics
  • Demonstrable success in general molecular and cellular biology (tissue culture) techniques
  • Experience with the generation of stable cell lines
  • Preferably an understanding of the challenges in viral vector manufacturing and scale-up
  • Preferably an understanding of the generation of AAV stable cell lines
  • An understanding, and preferably first-hand experience, in risk-assessing GMs

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives

No agencies please

 


We offer:

 

 

 

We are a pioneering gene therapy business, and our mission is delivering life changing gene therapies to patients. We work together, motivated to make a difference, and so can you.

We are pioneers; no one else does what we do.

Gene therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells. It is transforming medicine as we know it, long term and potentially curative treatments for a wide range of diseases are now possible.

We are at the forefront of this exciting area. We have a strong reputation in gene therapy, with world leading expertise in lentiviral vectors. We have a leading, integrated platform of exclusive technologies to design, develop and bioprocess unique gene based medicines, both in house and with partners.

We drive credible science to realise incredible results.

Whether you’re motivated by the discovery and development of product candidates within Research, or by cutting edge tools and technologies including AI and automation of our contract development and manufacturing organisation, we can offer you a career like no other. We are excited about our future. Join us and change lives.

 

 

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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