Skip to main content

This job has expired

Principal Scientist, Vector Engineering

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire
Salary
Competitive
Start date
7 Sep 2021
Closing date
7 Oct 2021

View more

Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Management

Job Details

Job description:
 

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

This role is to lead the newly formed ‘AAV Vector Research’ (AVR) Team within Platform Research. The team will sit with the Vector Engineering Group (VEG), and the team lead will report to the Director of VEG. The purpose of the AVR team is to develop new expression systems for AAV vector component production by embedding existing OXB technology, and to conduct research into improving vector component expression cassettes.

Your responsibilities in this role would be: 

  • Driving AAV vector research by pursuing strategies to optimise vector component expression, some of which are already under development, but also by implementing your own ideas
  • Embedding generic existing OXB tech into AAV vector production systems
  • Line manage direct reports and ensure correct training/development of the team members in necessary techniques and general learning
  • Work closely with the Cell Engineering Group (CEG), Vector Purification Research (VPR), Analytical teams and Process R&D (PRD) in developing AAV production capabilities
  • Support/input into tech-transfer of customer AAV vector processes and/or feasibility studies may be required. The team lead will contribute to reports, patent applications and peer review articles.

To be successful in this role, you will have the following skills and experience: 

  • PhD and several years post-doctoral experience in a directly relevant field (i.e. AAV vectors) in either academia or industry
  • A deep understanding and practical experience of AAV vectorology
  • A wider understanding of the AAV life cycle and aspects of virology in general
  • Demonstrable success in general molecular and cellular biology (tissue culture) techniques
  • Preferably an understanding of AAV vector quality attributes and analytics
  • Preferably an understanding of the challenges in viral vector manufacturing and scale-up
  • An understanding, and preferably first-hand experience, in risk-assessing GMs
  • A good attention to detail and execution of lab work
  • Ability to critically evaluate their data
  • First-hand line management experience is ideal

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives

No agencies please

 


We offer:

 

 

 

We are committed to offering highly competitive reward packages for all our staff. That’s why, every year, we benchmark our salaries and benefits against the local pharmaceutical market – by that, we mean that we compare our packages with those of other major companies in the London, Oxford, Cambridge areas.

 

 

We’re looking for highly skilled, focused individuals to help us deliver life-changing therapies to patients. It’s no mean feat, and we have to work together to make this happen.

Along the way, you’ll have a rich variety of opportunities to really develop your career. We’ll also give you a generous set of employee benefits and a competitive salary.

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert