Skip to main content

This job has expired

Scientist II PRD (Downstream)

Employer
Oxford BioMedica (UK) Limited
Location
Oxford
Salary
Competitive
Start date
2 Aug 2021
Closing date
26 Aug 2021

View more

Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Graduate

Job Details

Job description:
 

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

 

Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.

 

We are currently recruiting for a Scientist II, Downstream to join the team.  The purpose of this role is to perform process development studies for the purification of therapeutics for process understanding and characterisation.

 

Your responsibilities in this role would be:

 

  • Involvement in activities ranging from vector purification, process optimization, technology transfer, and process validation activities associated with the purification of new gene therapy vectors
  • Executing routine chromatographic purification activities with affinity, size exclusion and ion exchange media using ÄKTA systems (Unicorn software)
  • Performing bench scale filtration experimentations such as sterile membrane filtration, depth filtration and tangential flow filtration
  • Performing high-throughput purification studies and applying DOE methods to separations and (pre)formulation activities
  • Developing novel purification processes as well as using standard methods to purify viral vectors
  • Performing, developing and optimising robust, efficient, scalable strategies for improving process performance; including small-scale studies and pilot scale purification studies
  • Analysing and interpreting data, and presenting/documenting the results at meetings. Generating reports and preparing scientific presentations as needed
  • Writing and revising SOPs and technical reports

 

To be successful in this role, you will have the following skills and experience:

 

  • a graduate or postgraduate degree (or equivalent qualification) in a relevant scientific discipline
  • a sound understanding of basic purification principles and processes
  • fluency in written and spoken English
  • pharmaceutical industry experience in biological research and development or equivalent experience gained elsewhere is desirable
  • hands-on experience with the operation of laboratory, pilot or production scale ÄKTA purification systems
  • experience with cell culture

 

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

 

Collaborate. Contribute. Change lives.

 

No agencies please

 


We offer:

 

 

 

We are committed to offering highly competitive reward packages for all our staff. That’s why, every year, we benchmark our salaries and benefits against the local pharmaceutical market – by that, we mean that we compare our packages with those of other major companies in the London, Oxford, Cambridge areas.

We’re looking for highly skilled, focused individuals to help us deliver life-changing therapies to patients. It’s no mean feat, and we have to work together to make this happen.

Along the way, you’ll have a rich variety of opportunities to really develop your career. We’ll also give you a generous set of employee benefits and a competitive salary.

 

 

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert