With operations in 35+ nations and ~ 27,000 employees worldwide, CSL is driven to develop and deliver a broad range of lifesaving therapies to treat disorders such as hemophilia and primary immune deficiencies, and vaccines to prevent influenza. Our therapies are also used in cardiac surgery, organ transplantation and burn treatment.

CSL is the parent company of CSL Behring and Seqirus. CSL Behring is a global leader in the protein biotherapeutics industry, focused on bringing to market biotherapies used to treat serious and often rare conditions. CSL Behring operates CSL Plasma , one of the world's largest collectors of human plasma, which is used to create CSL's therapies. Seqirus is the second largest influenza vaccine company in the world and is a transcontinental partner in pandemic preparedness and a major contributor to the prevention and control of influenza globally.

We invite you to take a look at the many career possibilities available around the globe and consider building your promising future at CSL by becoming a member of our team!

The Opportunity

We have a 12 month fixed-term opportunity available for a Research Scientist to join the CSL Research team, based at Bio21 Institute. This exciting role, based within the Research & Clinical Bioanalytics Department, will be bench based, utilising the successful applicants experience and expertise to lead activities in identifying, establishing, developing and implementing specialised (non-routine) bioassays to support Research & Development of novel therapeutic proteins.

The successful applicant will join a research focussed, high profile, laboratory-based team that works at the interface between research and clinical development. You will devise, develop and implement high quality, regulatory compliant bioanalytical (PK, ADA) and biomarkers assays, providing data from such assays to allow scientifically informed decision making in research, toxicology and clinical development studies. You will assess all aspects of the feasibility of such bioanalytical or biomarker assays for inclusion in research, GLP toxicology and clinical studies (e.g. reagent provision and life cycle, assay design and robustness, compliance to appropriate regulatory standards (GLP and GCLP), sample collection, transport logistics and clinical practice). You will establish/adapt assay methods whilst verifying/validating that assays are "fit for purpose". You will also need to have and maintain a high-level awareness of key scientific/technical strategies and innovative technical developments in your areas of expertise as well as being up to date with key literature in the relevant therapeutic indications and regulatory GLP and GCLP guidelines and policies. Research experience relating to any of CSL's core Therapeutic Areas (Immunology, Cardiovascular and Metabolism, Haematology, Transplant and Respiratory) will be highly regarded.

You will ideally have expertise in some of the below techniques:

• Ligand binding assays e.g. ELISA or alternative platforms
• Flow Cytometry
• Cell-based bioassays (signalling, receptor/binding occupancy, cytotoxicity, immunophenotyping etc.)
• Cytokine / inflammatory biomarker assays
• Analytical biochemistry methods
• In and ex vivo assay methodologies using animal or human samples to develop/validate models that allow:
  • Measurement of PK of therapeutic proteins
  • Measurement of immunogenicity of therapeutic proteins
  • Measurement of dynamic modulation of target mechanism / biology (i.e. development of pharmacokinetic/pharmacodynamic models)
  • Demonstration of the relationship between biomarker modulation and outcome

To be successful

You will hold a post-graduate qualification with at least 2 years experience in pre-clinical and clinical development of biopharmaceuticals or equivalent related experience in industry and/or academia. You will lead the science from the bench for the development, validation and execution of relevant new assays and established assays (assay life cycle).

The successful applicant will have excellent communication/networking skills as the position requires close interaction with our research colleagues and early/late phase clinical development groups across the CSL global sites (Melbourne, Marburg, Bern, King of Prussia). An excellent problem solver with practical application to lab techniques and instrumentation, you will be a 'self starter' and undertake novel approaches to basic scientific questions. The applicant will require to have outstanding record keeping skills with the attention to detail as well as excellent organisational and management skills as part of a highly performing team.

Applications close 22 August, 2021

Employment screening, including criminal history, medical assessment, confirmation of experience and stated qualifications, Australian working rights and other relevant checks form part of the candidate suitability

Worker Type:
Employee

Worker Sub Type:
Fixed Term (Fixed Term)