Director, Translational Science
- Employer
- Oxford BioMedica (UK) Limited
- Location
- Oxfordshire
- Salary
- To define
- Start date
- 23 Jun 2021
- Closing date
- 23 Jul 2021
View more
- Discipline
- R & D , Biotechnology, Scientific
- Hours
- Full Time
- Contract Type
- Permanent
- Experience Level
- Director/Executive
Job Details
Job description:
Do you want to develop your career in exciting new medical technologies? We deliver life-changing gene therapies to patients, and so can you.
Oxford Biomedica’s Translational Sciences Group is responsible for supporting and optimising the development of internal and external therapeutic products through preclinical and clinical research, utilising high quality bioanalytical assays to provide a detailed understanding of safety and efficacy parameters
We are currently recruiting for a Director to join the team. The purpose of this role is to lead, direct and manage the effective performance of a team of scientists undertaking analytical work (GxP and Research) and to oversee the timely delivery of projects for both internal and commercial partners. Also, acts as Test Facility Management (the person who has the authority and formal responsibility for the organisation and functioning of the test facility according to the principles of OECD-Good Laboratory Practice)
Your responsibilities in this role would be:
- Accountable for the day-to-day operational performance of TSG’s analytical capability, with tactical focus on continuous improvement of the Department’s portfolio of varied GxP analytical offering.
- Support the development of a portfolio of gene therapy products through pre-clinical and clinical testing by providing a suite of “regulatory required” and/or “value-adding” analytics performed using cutting-edge assays and equipment.
- Manage and direct analytical work. Review, interpret and present data and produce reports suitable for Regulatory filings, publications or for business development activities.
- Identify and engage with external experts or academic groups to deliver collaborative projects that will advance product development goals.
- Identify future analytical requirements for new products to ensure efficient progress through the required developmental stages and to maximise the value of the product.
- Maintain awareness of external technologies and the GxP Regulatory landscape and advise and respond accordingly in order to ensure that OXB remain at the forefront of the analysis of the safety and efficacy of gene therapy products.
- Initiate and manage focussed research that will benefit aspects of the product development pipeline e.g. development of new biomarkers which would facilitate the early assessment of product safety or efficacy.
- Management of project work including the generation of work packages, establishing project timelines, efficient resourcing and clear communication with both internal and external clients.
- Proactively identify risks and issues to the relevant internal stakeholders and external collaborators at an early stage.
To be successful in this role, you will have the following skills and experience:
PhD or equivalent degree in a relevant Science (e.g. Biological sciences, Immunology, Virology, Medical Science, Molecular/Cellular biology)
Extensive experience in the Biotech/Pharma sector with a focus on analytical testing on ATMPs
Extensive knowledge and practical experience of five or more of the following areas: GxP / Regulatory documentation, gene therapy/ATMPs, viral vectors, cell biology, Biopharmaceutical industry, analytical techniques, high through-put technologies.
A deep understanding of Quality systems, Regulatory requirements and GxP compliance.
From a deep scientific understanding of diverse gene therapy products, will be able to identify analytical requirements which will meet Regulatory requirements and ideally, add value to the product.
Capable of disseminating key advances within related scientific fields that affect current R&D activities.
Extensive understanding of the R&D activities across internal departments and an ability to build working relationships across teams.
A strong track record in gene therapy and analytics (Industrial experience and/or strong publication record).
Proactively seek continuous Quality and analytical improvements (i.e. identify gaps & recommend improvements).
Interpret new Regulatory guidance and ensure timely delivery of appropriate, compliant and industry-leading analytical tests.
Provide insight and recommendations regarding how external technologies may be applied in novel or more efficient ways to add value to internal or external client products.
Conceive novel strategies and drive areas of research accordingly towards generation of patents and/or company trade secrets, or to navigate restrictive patent landscape.
Nurture a culture of creativity, collaboration and innovation within the Department
Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.
Collaborate. Contribute. Change lives
No agencies please
We offer:
We are committed to offering highly competitive reward packages for all our staff. That’s why, every year, we benchmark our salaries and benefits against the local pharmaceutical market – by that, we mean that we compare our packages with those of other major companies in the London, Oxford, Cambridge areas.
We’re looking for highly skilled, focused individuals to help us deliver life-changing therapies to patients. It’s no mean feat, and we have to work together to make this happen.
Along the way, you’ll have a rich variety of opportunities to really develop your career. We’ll also give you a generous set of employee benefits and a competitive salary.
Company
Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.
Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).
Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise.
Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.com, www.oxbsolutions.com, and follow us on LinkedIn, Twitter and YouTube.
Life at Oxford Biomedica
We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.
Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.
No matter who you are, or what you do, your work will make a significant difference.
We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.
We have access to like-minded scientists and engineers, working in the latest technologies.
Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.
Our supportive culture invites talent, while creating future innovators.
We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning. Our defined career pathways provide opportunities for everyone to achieve their career potential. We make a difference, and so can you.
- Website
- http://www.oxb.com/
- Telephone
- +44 (0) 1865 783 000
- Location
-
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom
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