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Senior Scientist, Cell Engineering

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire
Salary
To define
Start date
21 Jun 2021
Closing date
24 Jun 2021

View more

Discipline
R & D , Biotechnology, Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

Job description:

We drive credible science to realise incredible results, and so can you.

 

Oxford Biomedica’s (OXB) Cell Engineering Group (CEG) is part of the Platform Research Department and its primary function is to develop stable cell lines, which will ultimately be used for the production of lentiviral vectors (LVs) for therapeutic use.

 

CEG is seeking to recruit an experienced scientist, who will be required to plan, execute and report experiments as well as supporting other members of the team as needed. The successful candidate will have skills and experience with tissue culture and molecular biology. Experience with LV production, especially in bioreactors would be an added advantage.  Experience with the training of junior scientists would be a further benefit.

 

Your responsibilities in this role would be:

 
  • Provide direction for a small group of scientists and/or projects in line with company objectives.
  • Accountable for CEG project activities, which may involve LV production (small scale to bioreactor scale), LV characterisation, analytical assays, plasmid design and development
  • Management of projects often consisting of multiple experiments and delivery of agreed project outputs.
  • May have responsibility for one or more junior scientists and their projects, with direction provided by Director/Group Lead.
  • Responsible for ensuring that all experimental data from direct reports and projects are submitted to PatentSafe in a timely manner
  • Generation of high quality written reports for internal and / or client review as well as providing proof reading support to colleagues
  • Maintain a high standard of record keeping and documentation of experiments and investigations to ensure that information is captured clearly and timely.
  • Analyse and interpret data for documenting and reporting at internal meetings, client meetings and external venues such as conferences.
  • Collaborate across departments to align relevant procedures within the role. 
  • Share scientific skills through training and mentoring other scientists in the department by providing operational support where applicable.
  • Contribute and present at regular team/department/project meetings and presentations
  • May be responsible for management of a laboratory area and/or important equipment.
  • Personally responsible for the completion of tasks in relation to their criticality.
  • Maintain excellent laboratory citizenship

 

To be successful in this role, you will have the following skills and experience:

 
  •         BSc, MSc or PhD in an applicable Bioscience with significant relevant experience for the role.
  •         Extensive experience of general cellular, molecular biology techniques and analytical assays
  • Practical experience with tissue culture, flow cytometry, nucleic acid extractions, qPCR, western blot and plasmid cloning.   
  • It would be an advantage to have experience with any of the following: LV production, bioreactor operation, gene editing techniques, analytical assays (e.g. qPCR, ddPCR, FACS)
  • Knowledge in Virology and Gene Therapy

 

D     Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

 

Collaborate. Contribute. Change lives

 

No agencies please



Profile description:

This is the Profile description box in SF

We drive credible science to realise incredible results, and so can you.

Oxford Biomedica’s (OXB) Cell Engineering Group (CEG) is part of the Platform Research Department and its primary function is to develop stable cell lines, which will ultimately be used for the production of lentiviral vectors (LVs) for therapeutic use.

CEG is seeking to recruit an experienced scientist, who will be required to plan, execute and report experiments as well as supporting other members of the team as needed. The successful candidate will have skills and experience with tissue culture and molecular biology. Experience with LV production, especially in bioreactors would be an added advantage.  Experience with the training of junior scientists would be a further benefit.

Your responsibilities in this role would be: 

  • Provide direction for a small group of scientists and/or projects in line with company objectives.
  • Accountable for CEG project activities, which may involve LV production (small scale to bioreactor scale), LV characterisation, analytical assays, plasmid design and development
  • Management of projects often consisting of multiple experiments and delivery of agreed project outputs.
  • May have responsibility for one or more junior scientists and their projects, with direction provided by Director/Group Lead.
  • Responsible for ensuring that all experimental data from direct reports and projects are submitted to PatentSafe in a timely manner
  • Generation of high quality written reports for internal and / or client review as well as providing proof reading support to colleagues
  • Maintain a high standard of record keeping and documentation of experiments and investigations to ensure that information is captured clearly and timely.
  • Analyse and interpret data for documenting and reporting at internal meetings, client meetings and external venues such as conferences.
  • Collaborate across departments to align relevant procedures within the role. 
  • Share scientific skills through training and mentoring other scientists in the department by providing operational support where applicable.
  • Contribute and present at regular team/department/project meetings and presentations
  • May be responsible for management of a laboratory area and/or important equipment.
  • Personally responsible for the completion of tasks in relation to their criticality.
  • Maintain excellent laboratory citizenship

To be successful in this role, you will have the following skills and experience:

  • BSc, MSc or PhD in an applicable Bioscience with significant relevant experience for the role.
  • Extensive experience of general cellular, molecular biology techniques and analytical assays
  • Practical experience with tissue culture, flow cytometry, nucleic acid extractions, qPCR, western blot and plasmid cloning.   
  • It would be an advantage to have experience with any of the following: LV production, bioreactor operation, gene editing techniques, analytical assays (e.g. qPCR, ddPCR, FACS)
  • Knowledge in Virology and Gene Therapy

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives

 

No agencies please



We offer:

We are committed to offering highly competitive reward packages for all our staff. That’s why, every year, we benchmark our salaries and benefits against the local pharmaceutical market – by that, we mean that we compare our packages with those of other major companies in the London, Oxford, Cambridge areas.

We’re looking for highly skilled, focused individuals to help us deliver life-changing therapies to patients. It’s no mean feat, and we have to work together to make this happen.

Along the way, you’ll have a rich variety of opportunities to really develop your career. We’ll also give you a generous set of employee benefits and a competitive salary.

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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