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Scientist IV, Computer Aided Biology

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire (GB)
Salary
Competitive
Start date
14 Jun 2021
Closing date
14 Jul 2021

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Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

We are currently recruiting for a Scientist IV, Computer Aided Biology to join the Platform Research Group.  The purpose of this role is to plan, execute and report laboratory-based experiments or analytical investigations in accordance with scientific or regulatory requirements, in alignment with department objectives

Your responsibilities in this role would be:

- To assist in the implementation of digitally enabled robotics targeting key bottle necks in analytical testing 

- To develop lab automation workflows

- To liaise with analytical departments (GMP and Research) in order to facilitate the execution of high-throughput automated protocols

- To assist with the execution of large batch experiments for Process Characterisation across different departments

- To perform data analysis using complex Excel spreadsheets

- To assist with the implementation of ELN for automated workflows

- To write, revise SOPs and provide training

- To develop new lentiviral vector transduction workflows on automated liquid handlers

- To assist in the execution of complex Design of Experiments (DoE) protocols

- Accountable for own performance in alignment with group objectives and deadlines. Design and conduct experiments /investigations in accordance with  correct methodologies and procedures under the direction of the Group Leader or senior scientist.

- Ensure a high standard of record keeping and documentation of experiments and investigations in order that information is clearly captured and disseminated and reported.

- Present scientific data at internal meetings and external venues such as conferences.

- Will report to the Group Leader or his/her delegated grade 5 to 6 scientist.

- Conduct research and technical support of the highest quality, largely in a single project area but will assist in other projects as the need arises.

- Ensure experimental data is submitted to PatentSafe in a timely manner.

- May be responsible for maintenance of a laboratory area and/or important equipment.

- Personally responsible for the completion of tasks in relation to their criticality.

- Joint responsibility for maintenance and compliance of a GxP laboratory area and GxP “housekeeping” procedures.

- Work will be conducted in accordance with the OXB quality management system.

- Writing and reviewing of departmental documentation and SOP’s.

- Preparation of reports and documents to support GxP and regulatory activities.

To be successful in this role, you will have the following skills and experience:

- Minimum BSc Degree programme level with relevant experience

- Where required a detailed knowledge and experience of GxP

- Knowledge in Virology and gene therapy would be an advantage

- Laboratory technical experience with particular emphasis on one or more of the following: Tissue Culture, qPCR Molecular Biology and protein chemistry

- Experience with digitally enabled robotics and automation

- Good experience in sterile cell culture using mammalian cells

- Extensive research and development background in protein and molecular biology techniques (nucleic acid extraction, quantitative real-time PCR, ELISA)

- A strong background in assay development

- Experience of automated data analysis and/or visualization software e.g. JMP

- Desirable experience in flow cytometry

- Desirable knowledge of different coding languages

- Desirable experience in working in GMP-like environments

- Demonstrate competency in performing laboratory tasks and general experimental procedures with expertise in one or more areas.

- Understanding of laboratory health and safety requirements.

- Competency in data capture reporting and management systems e.g. PatentSafe and archiving.

- Sufficient understanding of the overall activities in the department to contribute useful ideas at meetings.

- Familiar with the literature relating to project area.

- Capable of interpreting results from experiments and drawing conclusions but may need guidance from senior scientists.

- Capable of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives.

- Good knowledge of the overall research programme in your group.

- Competent in the use of PatentSafe system that operates at OXB and submission of documents to PatentSafe in a timely manner.

- Detailed knowledge of regulatory requirements e.g. GMP, GLP, GCP and/or Validation and Quality Management systems.

- Detailed knowledge of the Quality management reporting structure/responsibilities within OXB.

- High regard for safety and display a high level of good laboratory citizenship.

- Detailed knowledge of the regulatory requirements for analytical work (e.g. product specifications, stability testing guidelines etc) is required.

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives

No agencies pleas

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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