Senior Scientist, In Vitro, Oncology Research

Cambridgeshire, England
25 May 2021
22 Jun 2021
R & D , Scientific
Full Time
Contract Type
Experience Level
Experienced (non-manager)

Senior Scientist, In vitro, Oncology Research

Location: Cambridge UK

Do you have expertise in, and passion for, immune-Oncology? Would you like to apply your expertise to impact the lives of patient's living with cancer in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!


AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies…

A place built on courage, curiosity and collaboration - we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.

At AstraZeneca, we're proud to have a unique workplace culture that inspires innovation and collaboration. Here, employees are empowered to express diverse perspectives - and are made to feel valued, energized and rewarded for their ideas and creativity.


Welcome to Granta Park Cambridge, one of over 400 sites here at AstraZeneca!

Providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca's priorities, it's important to us that you bring your full self to work every day.

To help you maintain your best self, here's a sneak peek into some of the things this site provides for you… Granta Park has a gym, nursery and central restaurant/coffee place as part of the science park facilities that are accessible to our staff. We also have our own bistro and deli in the AZ buildings. There are regular lunch & learn events and after work socials with snacks/beer/wine on the last Friday of every month. This is our biggest and most spacious lab site - come and join us!


In the Oncology Business Unit we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease.

Fast-paced and ever-changing, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus and a sense of urgency to seek the unanswered questions - innovating, challenging accepted norms, quick decision-making and taking smart risks. A place of trust, it's an opportunity to take accountability, be brave, speak up, step up and disrupt to change the game for Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp.

AstraZeneca's vision in Oncology is to push the boundaries of science to change the practice of medicine, transform the lives of patients living with cancer, and to ultimately eliminate cancer as a cause of death. A broad pipeline of next-generation medicines is focused principally on four disease areas - breast, ovarian, lung and haematological cancers.

We are seeking a highly motivated Senior Scientist in Immuno-Oncology with deep scientific and technical expertise in adaptive immune cell biology specifically focusing on T cell immunology, with a track record of scientific excellence to join our team in Cambridge, UK. As a Senior Scientist you will be a key member of a team focussed on supporting immune-oncology projects through the drug discovery process. You will bring your theoretical and practical expertise in immunology to establish assay systems and deliver datasets that will have direct impact on immune-oncology research projects.

Main Duties and Responsibilities

Working in this laboratory-based position within the Immuno-Oncology Research group you will develop, design, conduct and analyse in vitro experiments to assess the function of our candidate drugs and help to dissect the mechanism of action of novel therapeutics targeting the immune system for cancer therapy. You will also review emerging literature and internal data to help in identifying new potential targets and contribute to target validation activities.

A strong foundation in immunology / immuno-oncology, and depth of expertise in techniques for the analysis of immune function and phenotype is essential for this role. As a highly organised, self-motivated individual with a strong lab/practical background you will stay up to date with relevant technical and intellectual scientific expertise in tumour immunology and have a genuine passion for this field of research.

Essential Requirements:

  • A PhD, or equivalent experience, in immunology and/or immuno-oncology.

  • Deep expertise in T cell immunology, cytokine biology plus broad understanding and enthusiasm for translating basic science into novel cancer therapies

  • Deep expertise working with immune cells and in vitro / ex vivo co-cultures

  • Experience of a range of in vitro skills for the analysis of human immune cell function e.g. multiparameter flow cytometry and analysis using dimensionality reduction, ELISA, primary immune cell co-cultures, molecular biology skills including transcriptomics, single cell sequencing, assessment of intracellular signaling and generation of engineered cell lines

  • Strong interpersonal, influencing, negotiating and collaboration skills together with evidence of having used these to support problem solving and delivery in a team-oriented, collaborative environment.

  • Depth of understanding and enthusiasm for immunology and immuno-oncology

  • Proven track record of success in your research

  • Data processing, statistical analysis and interpretation.

  • Experience preparing written scientific reports (e.g. manuscripts) and oral presentations (e.g. slides, posters).

  • Experience with visualizing/quantitating high content multi-parameter flow data and evaluation of transcriptomic datasets

    Experience working with patient-derived tumours/organoids/TILs an advantage

    Knowledge of the drug discovery process

  • Publications in top tier scientific journals

Desirable Requirements
  • Experience with protein engineering and antibody design

  • Expertise in field of T cell exhaustion

Why AstraZeneca?

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit.

There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

So, what's next?

Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.

If you're curious to know more, please reach out to arrange a confidential discussion. We welcome your application and hope to be hearing from you soon!

Competitive salary and benefits package on offer.

The successful candidate will have access to a flexible employee benefits fund, including holiday purchase and flexible time off, pension contributions, Share Save Plans, A performance recognition scheme and a competitive, generous remuneration package.

Closing date: 26th June 2021

Where can I find out more?

Our Social Media, Follow AstraZeneca on LinkedIn

Follow AstraZeneca on Facebook

Follow AstraZeneca on Instagram

Similar jobs

Similar jobs