Seuss +

Senior Scientist CNS Disease Biology

Seuss +
03 May 2021
02 Jun 2021
Full Time
Contract Type
Experience Level
Experienced (non-manager)
Senior Scientist CNS Disease Biology

Our client is dedicated to bringing innovative therapies or unmet medical needs to patients. In doing so each function is directly or indirectly responsible for the lives of patients. This responsibility should be part of our day-to-day working life by (i) living up to high quality standards and (ii) recognizing the sense of urgency in areas of high medical need.

Purpose of the role
We are looking for a highly motivated and inquisitive (Senior) Scientist Disease Biology to support the development of (novel) of gene therapies for CNS disorders.

Place in the Organization
The position is based in the Research Department (Amsterdam), within the CNS Disease Biology group.

The key activities of the group are to develop novel gene therapy strategies for the treatment of CNS disorders of high unmet medical need. To this end, a deep understanding of underlying mechanisms of CNS disease is needed, to be applied to the strategy and design of innovative therapeutic approaches. The CNS disease biologist scientist is, together with the broader team, responsible of bringing scientific excellence to the program. She/he is also responsible of developing novel methods, tailored to the known mechanism-of-action of each given gene therapy approach, aimed at showing therapeutic efficacy, in vitro and in preclinical studies.

Key result areas (major duties, accountabilities, and responsibilities)
  • Synthesizes the input from a multidisciplinary project team in order to make decisions, and to set project priorities.
  • Participates in strategy, study design and implementation of dedicated mechanistic studies to understand basic questions on underlying biology of CNS disease targets, and gene therapy approaches with therapeutic potential.
  • Analyses complex data obtained from pre-clinical studies (in vitro and in vivo)
  • Strong (molecular) biological knowledge to understand obtained results and place them into the context of program development.
  • Hands-on laboratory and data analyses performed in with little supervision.
  • Experience in supervising a small team of (jr.) technicians.
  • Brings up his/her ideas about the line of research and, upon mutual agreement, implements the new ideas and concepts, disseminates, and reports the results.
  • Plans her/his own work, sets priorities and timelines, and adheres to these timelines.
  • Is quality orientated (i.e., detail and data critical) and she/he evaluates his/her own behavior and corrects her/himself if needed. She/he proposes ways to improve quality and throughput.
  • Disseminates results to multiple internal stakeholders.
  • Writes reports for internal purpose, and if possible external purposes.
Qualifications & Skills
  • Successfully completed PhD or equivalent, in cell biology, medical biology or related topic, with proven strong knowledge in the field of neurodegenerative and/or neurocognitive disorders.
  • Demonstrated experience in mechanistic studies in disease models.
  • Experience with next-generation sequencing approaches, proteomics and/or metabolomics would be advantageous, including single-cell approaches.
  • Experience in analysing complex datasets using informatic tools.
  • Experience with in vitro cell models, including iPSC, is highly advantageous.
  • Hands-on experience in writing, presenting, and reviewing in research documents (reports, patents, publications etc.)
  • Excellent knowledge of the English language (verbal, written and scientific)
  • Pro-active attitude, flexible and professional
  • Excellent presentation and written skills
Core competencies
  • Outstanding planning and organizational capabilities to plan own workload.
  • Proactive attitude with high level of ownership and accountability
  • Enthusiastic team player with strong interpersonal effectiveness and collaboration skills
  • Strong analytical skills
  • People management skills
  • Clear communication and presentation skills in project teams and beyond
  • Flexible to act in a highly dynamic and demanding environment.

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