Senior Scientist, Translational Pathology, Image Analysis

Essex, England
29 Apr 2021
06 May 2021
AstraZeneca UK
R & D , Scientific
Full Time
Contract Type
Experience Level
Experienced (non-manager)

Do you have expertise in, and a passion for the delivery of Image Analysis solutions, here you will add value to the evolution of translational science for the global oncology group in AstraZeneca. You will have the opportunity to impact an industry-leading portfolio of programs; from early clinical development of novel therapeutics through to post-marketing opportunities that support approved targeted therapies! Come and join a company that follows the science and turns ideas into life changing medicines. AstraZeneca might be the one for you!

About AstraZeneca

AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world's most serious diseases. But we're more than one of the world's leading pharmaceutical companies.

Site description

Welcome to Chesterford Research Park, one of over 400 sites here at AstraZeneca. Providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca's priorities, it's important to us that you bring your full self to work every day. To help you maintain your best self, here's a sneak peek into some of the things this site provides for you…high quality lab and office facilities accommodating teams from our Oncology, BioPharmaceuticals R&D Organisations. Restaurant and bar facilities within the park along with space for recreational walks and jogging paths in 20 acres of grounds. The park hosts a health and fitness centre. This site is a 10-minute commute via car or regular shuttle bus to Cambridge City centre, easily accessible via regular running public transport.

Business area

We are a science-based, leading and decisive Oncology enterprise united in our vision to eliminate cancer as a cause of death. The pioneers, we make bold moves that transform the way cancer is treated and truly improve patient outcomes. With one of the broadest and deepest Oncology pipelines in the industry, there are many opportunities to work with new and novel drugs and help discover what's next. Supportive team players, we draw on diverse knowledge from across the business and external partners to come to bear on the toughest medical challenges. Empowered by the business and each other, we embody courage and curiosity - taking smart risks, challenging the norm and learning from failures. Be at the forefront of applying science to studies and using innovative approaches to create new possibilities. We take an inter-disciplinary approach including novel biomarkers, AI, novel endpoints and cutting-edge trial designs to shape the future of our business and Oncology.

What you'll do

We currently have an opportunity for a Senior Scientist to join the Translational Pathology Image Analysis group within the Oncology R&D Translational Medicine department, where you will be at the forefront of the evolution of translational science for the global oncology group in AstraZeneca. You will have the opportunity to impact an industry-leading portfolio of programs from early clinical development of novel therapeutics through to post-marketing opportunities that support approved targeted therapies!

In this role you will need to use the best available science and technology to both develop new biomarker assays in the laboratory and develop image analysis solutions to measure these biomarkers in clinical tissues. Using these techniques you will generate disease linkage data to guide indication selection and targeted patient populations, as well as measuring drug target engagement. This work will inform clinical decisions for selecting therapeutically relevant doses and schedules, as well as building our understanding of key cancer pathway interactions to guide rational drug combinations.

Essential for the role
  • PhD plus working experience or industry in a relevant field
  • Skilled in digital image analysis
  • Competent in microscopy and digital scanning
  • Skilled in development and validation of biomarker assays
  • Experience in manual or automated immunohistochemistry (brightfield or fluorescence)
  • Peer-reviewed publications in the field of translational pathology, image analysis or cancer biology

Desirable for the role

Although training will be given, experience in the following areas would provide a distinct advantage

  • Experience in HALO or Visiopharm for image analysis
  • Python coding knowledge
  • Experience in image analysis that uses artificial intelligence (AI)/ deep learning algorithms
  • Expertise in one or more AZ portfolio areas, including related biology and knowledge of translational approaches to developing therapeutics for cancer
  • Experience working with human tissues and tissue-based histopathology methods.
  • Experience of conducting studies for Good Clinical Practice (GCP)
  • Skills in developing multiplexed immunohistochemistry or in situ hybridization (ISH) assays
  • Career exposure to the pharmaceutical industry and the drug development process

Why AstraZeneca?

At AstraZeneca we're dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There's no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We're on an exciting journey to pioneer the future of healthcare.

So, what's next?

  • Are you already imagining yourself joining our team? Good, because we can't wait to hear from you.
  • Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.
  • If you're curious to know more then please reach out to Louise Bennett

Competitive salary package and benefits

Close Date: 07/05/2021

"As part of the application process for some roles at AstraZeneca, candidates may be asked to complete a series of online games, created by pymetrics, to assess certain candidate qualities to help evaluate potential match for the position. If the pymetrics process applies to this role, you will receive an email invitation with additional information following application. Once completed AZ will automatically receive your results - pymetrics will not be used solely in our decision-making process but will help us gather additional insight."

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