Paramount Recruitment

Principal Scientist - Human Genetics

Baden-Württemberg, Germany
Pension, bonus, healthcare
21 Apr 2021
19 May 2021
Seema Rana
R & D , Bioinformatics
Full Time
Contract Type
Experience Level
Experienced (non-manager)
Principal Scientist - Human Genetics!

Exclusive role with a top 20 Pharmaceutical company based in Germany!

We are working this role exclusively for a client who develops breakthrough therapies and innovative healthcare solutions in areas of unmet medical needs for both humans and animals. They focus on long-term performance.

They are now looking for a principal scientist to join their amazing team.
The successful candidate will have a proven track record in drug discovery in a large pharma company or biotech and have extensive experience with one of the following disease areas: metabolic diseases, autoimmune diseases, neurological/psychiatric diseases or cancer immunology.

Tasks & responsibilities

●As Principal Scientist you are accountable for establishing common genetic methods, such as GWAS / PheWAS, fine mapping, Mendelian Randomisation and Polygenic Risk Score based patient stratification.
●You drive the analytic development utilising population level genomics datasets to better characterise gene function and their roles in diseases.
●By collaborating with experimental, clinical and bioinformatics scientists, you support the design of studies for target and biomarker discovery and drive scientific and strategic priorities to accelerate portfolio advancement.
●You identify suitable statistical and machine learning methods, propose ideas and implement prototype workflows that are reproducible and self-contained (e.g. through R/python packaging, ideally containerised through Docker).
●Identifying external collaboration opportunities to help develop key analytical and pharmacological needs of the company is also part of your new profile.


●PhD in Statistical Genetics, Bioinformatics, Genetic Epidemiology, Computational Biology, Statistics, Computer Science or related fields
●Sound expertise in statistic genetics workflows and practices as well as fluency in applying common tool chains (e.g. GWAS/PheWAS, fine mapping, colocalization, mendelian randomisation, polygenic risk score based patient stratification)
●Extensive experience in statistical computing with proven expertise in relevant programming languages (e.g. R, Python)
●Relevant experience in drug discovery or biomedical research, ideally in applying genetic methodology to provide actionable insights for discovering and developing drug targets
●Established professional experience in the management of large human cohort data from case-control studies or biobanks as well as in designing and implementing statistical models for production
●Experienced organisational skills with an attention to detail; demonstrated project management skills in leading cross functional teams and an established, wide-ranging network with scientific communities

This is an exciting and challenging role which will require someone with strong interpersonal skills.

Our client is offering a competitive package, with excellent benefits which include a competitive salary, generous amount of vacation time, and numerous other benefits towards your wellness & financial health and work-life balance. Plus, an onsite gym, in-house doctor and best-in-class cafeterias and coffee bars to keep you energised and healthy!

For more information on this role, and to discuss the benefits on offer, please call me on

t: +44 (0)121 616 3404 | m: +44 (0)7985 635091 or Email

Keywords: Data, Engineer, Management, Analysis, Visualisation, Bioinformatics, Genomics, Discovery, Data, Lake, Graphs, Domains, Database, Semantic, Pharmaceuticals, Governance, SQL, Python, Germany, Data Steward, Curation, Principal Scientist, Genetics, Data Science, Immunocology, Biomarkers, Cancer, Drug Discovery

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