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Senior Scientist, Upstream

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire
Salary
Competitive
Start date
15 Apr 2021
Closing date
13 May 2021

View more

Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.

We are currently recruiting for a Senior Scientist, Upstream to join the team.  The purpose of this role is to plan, execute and report relevant upstream studies or investigations and to support and supervise other members of the team

Your responsibilities in this role would be:

  • Involvement in activities ranging from vector manufacture, process optimization, technology transfer, and process validation activities associated with the manufacture of new gene therapy vectors.
  • Develop and optimise upstream processes for producing lentiviral vectors, working within the Process R&D group.
  • Responsible for designing and co-ordinating execution of cell culture activities for scale-up/scale-down of existing bioprocesses.
  • Lead the design and execution of experiments/process characterisation/investigations in accordance with correct methodologies and procedures.
  • Responsible for planning and execution of deliverables associated with one or more projects.
  • Analyse and interpret experimental data and report to stakeholders within OXB and externally to clients.
  • Write, revise, review and approve SOPs, technical reports, and risk assessments, where appropriate.
  • Ensure that the experiments conducted within the team/project, and their interpretation and reporting, are of the highest quality.
  • Provide direction for a small team and/or projects in line with company objectives.
  • Ensure that all work carried-out in the laboratory is performed efficiently and safely, following OXB HSE procedures.
  • Carry out such other tasks as are required from time to time for the efficient running of the Company’s business upon request from your line manager or a Director of the Company.
  • Deputise for the Team Lead when required.

To be successful in this role, you will have the following skills and experience:

  • BSc, MSc or PhD (or equivalent) in a relevant Bioscience with an appropriate level of relevant experience.
  • Relevant laboratory experience in one or more of the following areas: Tissue Culture, qPCR, Molecular Biology or Protein Chemistry.
  • Advanced understanding of cell culture principles and processes.
  • An understanding of metabolite analysis in the context of mammalian cell culture and media development
  • Pharmaceutical industry experience in biological research and development or equivalent experience gained elsewhere
  • Demonstrated experience with suspension cell culture.
  • Experience with the operation of laboratory, pilot or production scale cell culture bioreactors.
  • Excellent aseptic technique.
  • Practical understanding of how own area of operation relates to the overall business of OXB.
  • Understanding of laboratory health and safety requirements.
  • Competency in data capture, reporting and management systems.
  • Capable of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives.
  • Knowledge of the overall research programme in your group.
  • Awareness of regulatory requirements e.g. GMP, GLP, GCP and/or Validation and Quality Management systems.
  • Familiar with data analysis software packages such as but not limited to Microsoft Excel, JMP, Design Expert™, Graphpad Prism
  • High level of familiarity with the current literature relating to research projects.

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives.

No agencies please

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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