Target-engagement/Pharmacodynamic Biomarker Expert

1 day left

USA, South San Francisco, California
14 Apr 2021
12 May 2021
R & D , Scientific
Full Time
Contract Type
Experience Level
Experienced (non-manager)

Target-engagement/Pharmacodynamic Biomarker Expert

At AstraZeneca, we win through science, it's at the heart of our every success. That science is only possible when we all work together - we'll always make sure you're clear about how your role is connected to our wider mission to really show what science can do!

The Integrated Bioanalysis (iBA) group within the Clinical Pharmacology and Quantitative Pharmacology department at AstraZeneca seeks an experienced scientist to develop target-engagement and pharmacodynamic biomarker assays to support therapeutic product programs at the Senior or Associate Principal Scientist level, commensurate with experience. The ideal candidate will have extensive laboratory experience in use of multiple platform technologies to develop biomarker assays, in-depth understanding of the drug-development process, and expertise in bioanalysis, biochemistry, or disease biology (e.g. cardiovascular, cancer, pulmonary/respiratory, inflammation). The role is based in South San Francisco, California.

Major Duties and Responsibilities
* Develop assays to quantify target-engagement &/or pharmacodynamic activities of AZ therapeutic products to soluble or cell-bound molecules
* Serve as the bioanalytical assay representative or lead scientist for one or more therapeutic programs at the pre-clinical or clinical development stages
* Interface with other functional area representatives (clinical pharmacologists, toxicologists, translational medicine representative, clinical scientists) to deliver on program goals
* Contribute to engagement efforts with Commercial Research Organizations (CRO) in assay transfer, validation and implementation of bioanalytical & biomarker assays

Educational Requirements and Qualifications
* PhD in relevant field (biochemistry, cell biology, immunology, cancer biology) and post-doctoral experience in related area

* 2-6 years of experience in biomarker &/or bioanalytical studies in biopharmaceutical setting
* Experience in developing target-engagement &/or pharmacodynamic biomarker assays for therapeutic products
* Experience utilizing any of the following technologies for assay development in biological matrices/fluids: electrochemiluminescence (e.g. MSD®), ultra-sensitive ligand-binding platforms (e.g. Quanterix® SP-X) or multi-parametric protein detection platforms (e.g. Olink®)
* Understanding of assay qualification process for therapeutic molecules
* Knowledge of Good Laboratory Practice (GLP) regulations
* Experience with cell-based assays using flow cytometry or ELISPOT is preferred
* Experience in developing clinical immunogenicity assays (ADA or Nab) is a plus

Special Skills/abilities
* Ability to manage multiple complex programs and delivery timelines concurrently
* Ability to work independently in a highly-matrixed organization to deliver on goals
* Excellent verbal and written communication skills

The position is based in South San Francisco.

South San Francisco is a single world-class facility in the Cove at Oyster Point, in the heart of the area's vibrant biotechnology and technology community. It's our newest site that's been designed to enable side-by-side talent to make the impossible, possible at the center of the biotechnology and high-tech industry.


AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It's our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees' varying needs, offers valuable choices, and is highly competitive.

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together.

Come and join our journey - Apply today!

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