Oxford BioMedica (UK) Limited

Scientist IV, Translational Science (9 month Mat Cover)

Location
Oxfordshire
Salary
Competitive
Posted
12 Apr 2021
Closes
27 Apr 2021
Ref
OXB-TSG-21-198
Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Contract
Experience Level
Experienced (non-manager)

Do you want to develop your career in exciting new medical technologies? We deliver life-changing gene therapies to patients, and so can you.

Oxford Biomedica’s Translational Sciences Group is responsible for supporting and optimising the development of internal and external therapeutic products through preclinical and clinical research, utilising high quality bioanalytical assays to provide a detailed understanding of safety and efficacy parameters

We are currently recruiting for a Scientist IV to join the team for a 9 month maternity cover.  The purpose of this role is to plan, execute and report analytical investigations for the biodistribution, persistence and shedding of EIAV/HIV based vectors in clinical and non-clinical samples, and perform release testing analytics, in accordance with GLP, GCP and GMP compliance, in alignment with department objectives

Your responsibilities in this role would be:

  • Provide analytical support to the Study Directors (SDs), Principle Investigator (PIs) and Analytical Project Managers (APMs)
  • Monitor the biodistribution, persistence and shedding  of EIAV/HIV vectors in clinical and non-clinical samples utilising a number of nucleic acid extraction techniques and PCR techniques in accordance with GCLP/GLP compliance
  • Ensure a high standard of record keeping, reporting and interpretation of results compliant with GLP, GCP and GMP regulations
  • Support the manufacture and release of EIAV/HIV vectors by performing FACS/ELISA analytics in accordance with GMP compliance
  • Perform quality control checks on assay packs for a variety of assay types
  • Support the maintenance of GLP and GMP compliant facilities, performing general laboratory duties, for example calibration, monitoring and cleaning of equipment
  • Drive continuous quality improvement with the compliance with GLP/GCP regulations
  • Assist with the improvement of current assays and the development and validation of new assays
  • Produce and maintain GxP documentation (SOPs, equipment files) to a high standard
  • Share scientific knowledge through regular team/department meetings and presentations
  • Personally responsible for the completion of tasks in relation to their criticality.

To be successful in this role, you will have the following skills and experience:

  • BSC/PhD or extensive relevant experience in an associated subject
  • A detailed knowledge and experience of one of GLP, GCP(Labs) or GMP compliance
  • Laboratory technical experience with particular emphasis on one or more of the following: in nucleic acid extractions from biological samples, qPCR, RT-qPCR, FACS analysis
  • Knowledge of regulatory requirements e.g. GMP, GLP, GCP and and Quality Management systems and ability to maintain compliance.
  • Competency in performing laboratory tasks and bio-analytical methodologies with expertise in one or more areas e.g. qPCR, nucleic acid extractions, FACS
  • Experience of molecular biology methodologies/techniques.
  • Competency in data capture reporting and management systems e.g. GxP data recording and archiving.
  • Good knowledge/experience of analytical instrumentation e.g. PCR, FACS and some understanding of qualification procedures.
  • Support the development, troubleshooting and validation of analytical methods.
  • Familiar with the literature in defined project area.
  • Capable of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives
  • Familiar with the literature in defined project area.

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives

No agencies please

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