ADME Scientist
- Employer
- Proclinical Staffing
- Location
- Basel, Switzerland
- Salary
- Negotiable
- Start date
- 5 Mar 2021
- Closing date
- 19 Mar 2021
View more
- Discipline
- R & D , Scientific
- Hours
- Full Time
- Contract Type
- Permanent
- Experience Level
- Experienced (non-manager)
Job Details
Job Responsibilities
- Conduct the laboratory work in enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
- Analysing incubation samples via LC-MS/MS and radio-HPLC, including the method development and/or validation.
- Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and in drug development setting reporting to the respective laboratory staff and supervisors.
- Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
- Some time may be spent on supporting to develop new enzyme phenotyping methodologies and approaches.
Skills and Requirements
- PhD or Post Doc in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD)
- Min 3/5 years of experience in similar position
- Experience in bioanalysis & in vitro assays
- Experience in industry
- Excellent knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics assessment and the respective experimental designs.
- You have a strong interest in translational approaches leveraging in vitro data and clinical data.
- Working knowledge of regulatory expectations for enzymology studies (e.g. chemical inhibition, recombinant enzyme and correlation studies)
Company
At ProClinical we have one aim: to support life science companies in the many challenges they face while combatting unmet medical need worldwide.
Ageing populations, rare diseases, epidemics and the millions of patients without access to medication are just a few of the pressing issues that life science companies contend with. The industry is under increasing pressure to develop new and innovative ways to save and improve patients’ lives.
ProClinical’s mission is to support their work by connecting life science companies with the highly skilled professionals they need to continue innovating.
Internal recruitment and HR teams often struggle to continuously source skilled, experienced professionals to fill highly-specialised and niche roles. ProClinical combines a deep understanding of the industry with extensive candidate networks to provide both a technical and cultural fit for our life science partners.
- Website
- https://www.proclinical.com/
- Telephone
- 0800 988 4437
- Location
-
Eldon House
Eldon Street
London
EC2M 7LS
United Kingdom
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