Clinical Pharmacometrician

USA, Gaithersburg, Maryland
21 Feb 2021
21 Mar 2021
R & D , Pharmacology
Full Time
Contract Type
Experience Level
Experienced (non-manager)

Do you have expertise and experience in mathematical modelling and simulation, PKPD and its application in drug development? Would you like to apply your expertise in a company that is following the science and turn ideas into life changing medicines? Then you might be the one we are looking for!

This is an opportunity for a hardworking and engaged individual to join our growing Clinical Pharmacology and Quantitative Pharmacology (CPQP) team at AstraZeneca in Gothenburg (Sweden) or Gaithersburg (USA) and contribute as a Clinical Pharmacometrician supporting large and small molecule projects across all phases of clinical drug development within the therapy area of Cardiovascular, Renal and Metabolism.

AstraZeneca is a world-leading pharmaceutical company, focusing on discovering and developing medicines that make a real difference to millions of patients. Within the Clinical Pharmacology and Safety Sciences CPSS function, we have a state-of-the-art quantitative CPQP organization with a diverse and uniquely skilled team of clinical pharmacometricians, clinical pharmacology scientists and other specialists. You will thrive in an environment that inspires innovation, encourages multidisciplinary team-working and collaboration with academia, and rewards original scientific thinking.

What you will do:
Working closely with clinical pharmacology scientists, physicians and other scientists, you will apply model informed drug development (MIDD) to contribute to the clinical program, to support the design and interpretation of clinical studies and influence key decisions in early and late clinical development.

The work includes integration of relevant data, such as dose information, pharmacokinetics, biomarkers and clinical endpoints within and across studies, compounds and development stages. Use of simulations and informative pharmacometric/statistical analyses to inform trial and program designs and decisions are important focus areas for us. In collaboration with clinical pharmacology scientists, you will represent CPQP in cross-functional clinical project teams and be responsible for identifying and executing model informed drug development to accelerate and inform decision making. You will communicate your findings within and outside of AstraZeneca and publish in peer reviewed journals.

Depending on your previous experience and competencies, the level and responsibility of the position may be adjusted and tailored to suit you.

Essential in the role:

  • PhD or equivalent (M.Sc. or Pharm.D. ) level expertise in quantitative modelling , e.g. knowledge in mathematics and statistics applied to life sciences
  • Background in, and an understanding of clinical pharmacology aspects of drug development, preferably in both a small and large molecule setting
  • Good knowledge of pharmacokinetics, PKPD and its clinical applications
  • Biological understanding of disease and drug action
  • Good oral and written communication skills

Desirable in the role:

  • Track record in creating and delivering on MIDD strategies in clinical drug development programs for both small and large molecules
  • Recognized scientific expertise demonstrated by scientific publishing in the field of clinical pharmacology
  • Early or late phase clinical development experience/awareness.

Why AstraZeneca?

At AstraZeneca, when we see an opportunity for change, we seize it and make it happen, because any opportunity can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey in finding new ways to work, pioneering cutting edge methods and bringing unexpected teams together!

If this sound like the position and place for you - apply now!

Welcome with your application by March 26th, 2021, at the latest.

Where can I find out more?
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#clinicalpharmacometrician #CVRM

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