Associate Director, Translational PKPD Modeling & DMPK

England, Essex
14 Feb 2021
14 Mar 2021
R & D , Pharmacokinetics
Full Time
Contract Type
Experience Level
Senior Management

Associate Director, Translational PKPD Modeling & DMPK (Oncology)

Based in Cambridge, UK

AstraZeneca is a global biopharmaceutical company driven by what science can do. We are dedicated to discovering, developing, and delivering innovative, meaningful medicines and healthcare solutions that enrich the lives of patients!

The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients' lives.

To achieve this, we have an exciting and diverse portfolio that focuses on four scientific platforms that we believe show the greatest potential for yielding effective medicines for cancer patients. These scientific platforms include; Immuno-Oncology (IO), Tumor Drivers & Resistance (TDR), DNA Damage Response (DDR) and Antibody Drug Conjugates (ADC) and we are developing therapeutic agents across multiple modalities including; small molecules, biologics, Antibody Drug Conjugates (ADCs), nano-medicines and PROTACs.

The Oncology DMPK department provides drug metabolism & pharmacokinetic, as well as translational PKPD modeling & simulation support to our portfolio. Translational PKPD Modeling & Simulation scientists occupy high profile, visible roles within Early Oncology.

We are looking for a senior individual who has a passion for PKPD modeling and DMPK science, applied to Cancer biology, with the experience of working in both discovery and development.

Could this be you?

As a senior Translational PKPD Modeling & Simulation scientist, you will have the opportunity to drive strategy and provide global leadership in PKPD science across our diverse portfolio.

Your day-to-day role is to provide projects with expert modeling input into exploring the PK/PD/Efficacy in pre-clinical models, and using these models in order to iteratively build an understanding of the dose & schedule requirements for therapeutic intervention across different patient populations as a single agent and combined with other agents.

You will contribute to DMPK Modeling and Simulation by:

  • Representing Oncology DMPK and providing overall scientific leadership for cross functional and external collaborations involving DMPK.
  • Exploring the effects on target and pathway to understand the requirements for efficacy and set a candidate drug target profile (CDTP).
  • Predicting human dose and regimen together with providing input into exposure and pharmacodynamic (PD) biomarker based decision criteria for early clinical trials.
  • Driving learning through back translation of early clinical exposure and PD data and providing prioritized future options for clinical testing.
  • Leading and participating in Oncology strategic scientific initiatives and continuous improvement projects by providing expert M&S knowledge.
  • Having a breadth of influence and impact across AstraZeneca DMPK and externally within their discipline.
  • Identifying, championing and developing new ideas.
  • Leading scientific discipline networks and acting as a focus for debate within the AstraZeneca scientific community.
  • Advising on and participating in the development of Discovery or Development strategies in PKPD for biologics/ADCs/small molecules.
  • Managing student and Post Doc programmes.
  • Leading external collaborative projects with academic or cross-pharma pre-competitive groups.
  • Providing disciplinary scientific leadership and presenting work through patents, publications and lectures.

Minimum Requirements:

  • PhD or equivalent degree in a discipline with a significant component of Modeling & Simulation, such as systems biology, quantitative pharmacology, pharmacometrics, chemical engineering, physics, pharmaceutical sciences or applied mathematics.
  • Relevant industry experience in Modeling & Simulation, ideally in preclinical/translational setting, or a MS degree with proven industry experience.
  • Experience in a project-facing role within pharmaceutical R&D.
  • Comprehensive understanding of DMPK and pharmacology/safety aspects of drug discovery and development with a strong publication record.
  • Track record of supporting PK, PKPD and TKPD aspects of projects, with a delivery focus and ability to meet timelines to pre-specified quality and cost.
  • Specialist in tools such as WinNonLin/Phoenix NLME, NonMem, Berkeley Madonna, MATLAB, and SimCYP.
  • Excellent interpersonal and communication skills coupled with strong influence and leadership skills.
  • Experience in providing modeling support for other modalities in addition to small molecules is a plus.

If this describes you, we want to hear from you!

Next Steps - Apply today!

To be considered for this exciting opportunity, please complete the full application on our website at your earliest convenience - it is the only way that our Recruiter and Hiring Manager can know that you feel well qualified for this opportunity. If you know someone who would be a great fit, please share this posting with them.