Skip to main content

This job has expired

Principal Scientist, Team Lead - Upstream

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire
Salary
Competitive
Start date
1 Feb 2021
Closing date
1 Mar 2021

View more

Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Management

Job Details

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.

We are currently recruiting for a Principal Scientist, Team Lead - Upstream to join the team.  The purpose of this role is to be responsible for coordinating daily activities to ensure PR&D timelines are met, whilst maintaining compliance with GLP/GMP & safety regulations.

Your responsibilities in this role would be:

  • Responsible for the line management of a team of USP scientists and/or laboratory technicians; including managing performance, motivating the team and carrying out recruitment activities.
    • Manage and prioritise the team’s workload, ensuring results are delivered on time and at a high quality.
    • Ensure all direct reports or persons involved in projects are fully trained and maintain a high standard of record keeping and documentation of experiments so that information is clearly captured, disseminated and reported.
  • Perform, develop and optimise upstream processes for the production of lentiviral vectors, working within the Process R&D group.
  • Involvement in activities ranging from vector manufacture, process optimization, technology transfer, and process validation activities associated with the manufacture of new gene therapy vectors.
  • Provide upstream expertise and contribute to process design and scale-up, to deliver new and improved bio-manufacturing processes based on Quality by Design (QbD) using DoE.
  • Lead the design and execution of experiments/process characterisation/investigations in accordance with correct methodologies, policies and procedures.
  • Responsible for designing and co-ordinating the execution of upstream activities for scale-up/scale-down of existing bioprocesses across multiple bioreactor scales and platforms.
  • Analyse and interpret experimental data and report to stakeholders within OXB and to external clients.
  • As a subject matter expert, contribute to and/or lead troubleshooting and technical investigations as required.
  • Write, revise, review and approve SOPs, technical reports, and risk assessments, where appropriate.
  • Responsible for ensuring the GLP (and where necessary GMP) compliance of the laboratory and equipment.
  • Maintain a safe working environment by ensuring appropriate H&S training, risk assessments and COSHH assessments are in place.
  • Promote appropriate, effective communication within the team, with members of other departments, and with external collaborators.
  • Contribute to cross departmental activities and provide expert advice and technical input where needed.

To be successful in this role, you will have the following skills and experience:

  • BSc, MSc or PhD (or equivalent) in a relevant Bioscience with an appropriate level of relevant experience.
  • Relevant laboratory experience in one or more of the following areas: Tissue Culture, Upstream Bioprocessing, Molecular Biology or Protein Chemistry. is essential
  • Knowledge of bioprocessing scale-up, technology transfer, and/or process characterisation activities is essential
  • Good understanding of lentiviral vectors (or other gene therapy vectors), and associated product quality attributes.
  • Advanced understanding of cell culture principles and bioprocesses.
  • An understanding of metabolite analysis in the context of mammalian cell culture and media development.
  • Demonstrated experience with suspension cell culture.
  • Experience with the operation of laboratory, pilot or production scale bioreactors.
  • Competency in data capture, reporting and management systems, such as, but not limited to: Microsoft Excel, JMP, Design Expert™, Graphpad Prism
  • Awareness of regulatory requirements e.g. GMP, GLP, GCP, ICH and/or Validation and Quality Management systems.
  • Ability to provide direction and supervision for junior team members and direct reports, to deliver project/group/departmental objectives within the required timeframe.
  • Maintain a high ethical standard and a commitment to producing high quality work.

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives.

No agencies please

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

Get job alerts

Create a job alert and receive personalised job recommendations straight to your inbox.

Create alert