Senior Scientist, USP / Upstream Process

SENIOR SCIENTIST, UPSTREAM PROCESS VIRAL VECTOR

JOB PURPOSE

You will join Process Development team as the Upstream Process (USP) Senior Scientist where you will be involved in all aspects of USP process development for viral vector products. This is a brilliant opportunity for a talented scientist to take a leading role in the development novel viral vector products. You will work closely with the CMC USP team for transferring and supporting developed processes internally to CMC-Manufacturing and externally to cGMP contract manufacturing organisations.

Our client is looking for someone with the ability to succeed within a small biotech environment, with the ability to train, mentor, motivate, innovate and deliver a high standard of results!

KEY RESPONSIBILITIES

• Design, and execute experiments to develop and optimise mammalian cell culture batch and fed batch processes for novel viral vector products.
• Apply statistical approaches for process optimisation (DoE, QbD) at small scale and translation of small-scale results to process scale-up.
• Scale up of upstream processes (10-200L) to confirm process performance.
• Generate harvest material for purification by the downstream development group.
• Support technology transfer activities for clinical manufacturing.
• Ensure that all experimental and analytical data is documented following data integrity principles.
• Work collaboratively with Research, Cell Line Development, Downstream Process Development, Research Manufacturing and Quality to develop and establish new techniques and recommend alternative approaches and potential solutions to upstream process development issues.
• Ensure a healthy and safe working environment and compliance to GMO/ACDP requirements.

PROFILE SUMMARY

Education and Qualifications:

• PhD or BSc/MSc in Cell Biology, Virology or Biochemistry, Biotechnology, Molecular Biology, Biological Sciences, Biochemical Engineering with a viral vector focus, e.g., AAV, LVV, AV.

A highly motivated ambitious scientist with:

• Industry experience in mammalian suspension cell culture: batch and fed-batch process development, transient transfection, optimisation and scale up gained through the development of viral products.
• Some experience of basal medium and feed development, control, and optimisation.
• Some experience of developing upstream process control strategies.
• Understanding and experience of development and establishment of in-process analytical methods as applied to mammalian cell culture processes producing viral vector products.

 DURATION

Permanent / full-time

SALARY

Attractive package

LOCATION

South East UK – commutable from Berkshire, Buckinghamshire and Oxfordshire

ABOUT PLANET PHARMA

Planet Pharma is an American parented Employment Business/Agency that provides global staffing services with its head-quarters in Chicago and our EMEA regional office located in Central London. We have invested significantly in creating a robust international platform that enables us to work compliantly in 30+ countries with a current network of 2500+ active contractors globally as well as a very strong permanent / direct hire recruitment offering.

Our specialist knowledge and close relationships with our clients and the wider industry really makes us unique in our field. Just recently we were recognised by FORBES as the 17th best professional staffing firm, and have won multiple awards from industry accredited bodies for our commitment to excellence and service delivery. We have extensive functional expertise including: Regulatory Affairs, Pharmacovigilance, QA, QC, Submissions experts, Clinical development, Quality, Biostatistics, and Medical Affairs / Writing.

We are an equal opportunities Recruitment Business and Agency. We welcome applications from all suitably qualified candidates regardless of their race, sex, disability, religion/belief, sexual orientation or age.

www.planet-pharma.com