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Senior Scientist, DSP / Downstream Processing

Employer
Planet Pharma Staffing Limited
Location
South East England (GB)
Salary
Competitive package
Start date
23 Jan 2021
Closing date
22 Feb 2021

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Discipline
R & D , Laboratory, Pre - clinical, Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

SENIOR SCIENTIST, DOWNSTREAM PROCESS VIRAL VECTOR

JOB PURPOSE

You will join Process Development team as the downstream process development (DSP) Senior Scientist where you will be involved in all aspects of DSP process development for viral vector products. This is a brilliant opportunity for a talented scientist to take a leading role in the development novel viral vector products. You will work closely with the CMC DSP team for transferring and supporting developed processes internally to CMC-Manufacturing and externally to cGMP contract manufacturing organisations.

Our client is looking for someone with the ability to succeed within a small biotech environment, with the ability to train, mentor, motivate, innovate and deliver a high standard of results!

KEY RESPONSIBILITIES

  • Lead decision making of technical and scientific issues that affect, or have the potential to affect, the development and execution of DSP for the manufacture of biologics.
  • Develop, optimise, and establish robust, scalable and industry leading DSP processes to produce high quality novel viral vector products, meeting the requirements for quality and titre.
  • Provide scientific and technical leadership, in downstream process development and transfer into CMC Manufacturing or cGMP - for example process risk assessments, technology transfer and scale-up.
  • Deliver product specific and platform DSP documentation, process flow diagrams and reports ensuring appropriate quality of documentation to support inclusion of data and information in regulatory filings.
  • Work collaboratively with Research, Cell Line Development, Upstream Process Development, Analytical Development, CMC-Manufacturing and Quality to develop and establish new techniques and recommend alternative approaches and potential solutions to downstream processing issues.
  • Ensure a healthy and safe working environment and compliance to GMO/ACDP requirements.

PROFILE SUMMARY

Education and Qualifications:

  • PhD or BSc/MSc in Cell Biology, Biochemistry, Biotechnology, Food Science, Biological Sciences, Biochemical Engineering or a related field.

A highly motivated ambitious scientist with:

  • Ability to work independently.
  • Good conceptual, analytical thinking, problem solving, and organisational skills.
  • Ability to work in a high paced team environment, meet deadlines, and prioritise work from multiple projects.
  • Strong interpersonal and communication skills with demonstrated ability to work within a team environment.
  • Ability to balance multiple priorities and projects at the same time and be able to change priorities as needed by the business.
  • Experience in downstream process development/purification of viral vector products, from cell culture harvesting through to drug substance/purified product. This would have preferably been gained working with viral vectors such as LVV, AAV or AV.
  • Experience with chromatography systems such as Akta Purifier/Pure/Avant and a good understanding of chromatography techniques e.g., IEX/SEC/HIC/Affinity. Experience and understanding of tangential flow filtration are also desirable. Experience of scale-up of downstream processes to pilot scale would be a bonus.
  • Experience of routine analytical techniques such as SDS-PAGE, Western Blotting and biochemical assays is desirable.
  • Experience in the application DoE.
  • Knowledge of regulatory requirements for the development and manufacture of biologics using from mammalian cell culture is desirable.

 DURATION

Permanent / full-time

SALARY

Attractive package

LOCATION

South East UK – commutable from Berkshire, Buckinghamshire and Oxfordshire

ABOUT PLANET PHARMA

Planet Pharma is an American parented Employment Business/Agency that provides global staffing services with its head-quarters in Chicago and our EMEA regional office located in Central London. We have invested significantly in creating a robust international platform that enables us to work compliantly in 30+ countries with a current network of 2500+ active contractors globally as well as a very strong permanent / direct hire recruitment offering.

Our specialist knowledge and close relationships with our clients and the wider industry really makes us unique in our field. Just recently we were recognised by FORBES as the 17th best professional staffing firm, and have won multiple awards from industry accredited bodies for our commitment to excellence and service delivery. We have extensive functional expertise including: Regulatory Affairs, Pharmacovigilance, QA, QC, Submissions experts, Clinical development, Quality, Biostatistics, and Medical Affairs / Writing.

We are an equal opportunities Recruitment Business and Agency. We welcome applications from all suitably qualified candidates regardless of their race, sex, disability, religion/belief, sexual orientation or age.

www.planet-pharma.com

Company

Planet Pharma was founded by a dedicated team of professionals with extensive experience supporting the pharmaceutical, biotechnology, and device industries.

Our goal is to create an organization that strengthens the employer-employee dynamic by connecting clients with talent. This results in making staffing more personal and creating enduring, valuable relationships. We value communication with our clients and make it our priority to have the hiring process be as fast and successful as possible.

We leverage cutting-edge technology and flexible service delivery models that provide efficient, personalized solutions for your business.

Our global headquarters is in Northbrook, IL and branch offices are based across the United States and Europe.

Company info
Website
Telephone
+44 203 868 1000
Location
10 Greycoat Place
London
England
SW1P 1SB
United Kingdom

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