Syneos Health

CRA II - Netherlands

Location
Netherlands
Salary
Competative
Posted
04 Jan 2021
Closes
03 Feb 2021
Ref
EW/20009561
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

The Clinical Research Associate II (CRA II) will perform monitoring and site management activities for Phase I-IV clinical research projects to assess the progress of clinical projects at assigned investigative/physician sites (either on site or remotely) and to ensure clinical projects are conducted, recorded, and reported in accordance with the protocol, Company and Sponsor standard operating procedures (SOPs), ICH-GCP and/or all applicable local and federal regulatory requirements.  Performs all tasks routinely and independently, seeking guidance as needed.   JOB RESPONSIBILITIES

 

·        Performs site qualification, site initiation, interim monitoring, site management activities and close-out visits (performed on-site or remotely) ensuring regulatory, ICH-GCP and/or Good Pharmacoepidemiology Practice (GPP) and protocol compliance.  Uses judgment and experience to evaluate overall performance of site and site staff and to provide recommendations regarding site-specific actions; immediately communicates/escalates serious issues to the project team and develops action plans.  Maintains a working knowledge of ICH/GCP Guidelines or other applicable guidance, relevant regulations, and company SOPs/processes.

 

·        Verifies the process of obtaining informed consent has been adequately performed and documented for each subject/patient, as required/appropriate. Demonstrates diligence in protecting the confidentiality of each subject/patient. Assesses factors that might affect subject/patient’s safety and clinical data integrity at an investigator/physician site such as protocol deviation/violations and pharmacovigilance issues.

 

·        Per the Clinical Monitoring/Site Management Plan (CMP/SMP): 

 

o   Assesses site processes

o   Conducts Source Document Review of appropriate site source documents and medical records

o   Verifies required clinical data entered in the case report form (CRF) is accurate and complete

o   Applies query resolution techniques remotely and on site, and provides guidance to site staff as necessary, driving query resolution to closure within agreed timelines

o   Utilizes available hardware and software to support the effective conduct of the clinical study data review and capture

o   Verifies site compliance with electronic data capture requirements

 

·        May perform investigational product (IP) inventory, reconciliation and reviews storage and security. Verifies the IP has been dispensed and administered to subjects/patients according to the protocol. Verifies issues or risks associated with blinded or randomized information related to IP. Applies knowledge of GCP/local regulations and organizational procedures to ensure IP is appropriately (re)labelled, imported and released/returned.

 

·        Routinely reviews the Investigator Site File (ISF) for accuracy, timeliness and completeness. Reconciles contents of the ISF with the Trial Master File (TMF). Ensures the investigator/physician site is aware of the requirement of archiving essential documents in accordance with local guidelines and regulations. 

 

  • Documents activities via confirmation letters, follow-up letters, trip reports, communication logs, and other required project documents as per SOPs and Clinical Monitoring Plan/Site Management Plan.  Supports subject/patient recruitment, retention and awareness strategies.  Enters data into tracking systems as required to track all observations, ongoing status and assigned action items to resolution.

 

·        For assigned activities, understands project scope, budgets, and timelines; manages site-level activities / communication to ensure project objectives, deliverables and timelines are met.  Must be able to quickly adapt to changing priorities to achieve goals / targets. 

 

·        May act as primary liaison with study site personnel, or in collaboration with Central Monitoring Associate.  Ensures all assigned sites and project-specific site team members are trained and compliant with applicable requirements.

 

·        Prepares for and attends Investigator Meetings and/or sponsor face to face meetings.  Participates in global clinical monitoring/project staff meetings (inclusive of Sponsor representation, as applicable) and attends clinical training sessions according to the project specific requirements.      

 

·        Provides guidance at the site and project level towards audit readiness standards and supports preparation for audit and required follow-up actions.   

 

  • Maintains a working knowledge of ICH/GCP Guidelines or other applicable guidance, relevant regulations, and company SOPs/processes; completes assigned training as required.

 

  • For Real World Late Phase, the CRA II will use the business card title of Site Management Associate II.  Additional responsibilities include:

 

  • Site support throughout the study lifecycle from site identification through close-out
  • Knowledge of local requirements for real world late phase study designs
  • Chart abstraction activities and data collection
  • Collaboration with Sponsor affiliates, medical science liaisons and local country staff
  • The SMA II may be requested to train junior staff
  • Identify and communicate out of scope activities to Lead CRA/Project Manager
  • Proactively suggest potential sites based on local knowledge of treatment patterns, patient advocacy and Health Care Provider (HCP) associations                                                                     

Similar jobs

Similar jobs