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Scientist IV, Translational Services Group

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire
Salary
Competitive
Start date
20 Nov 2020
Closing date
18 Dec 2020

View more

Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

Our employees are able to develop their careers in exciting new medical technologies, and so can you.

We are currently recruiting for a Scientist IV to join our Translational Sciences Group.  The purpose of this role is to plan, execute and report analytical investigations for the biodistribution, persistence and shedding of EIAV/HIV based vectors in clinical and non-clinical samples, and perform release testing analytics, in accordance with GLP, GCP and GMP compliance, in alignment with department objectives

Your responsibilities in this role would be:

  • Provide analytical support to the Study Directors (SDs), Principle Investigator (PIs) and Analytical Project Managers (APMs)
  • Monitor the biodistribution, persistence and shedding of EIAV/HIV vectors in clinical and non-clinical samples utilising a number of nucleic acid extraction techniques and PCR techniques in accordance with GCLP/GLP compliance
  • Ensure a high standard of record keeping, reporting and interpretation of results compliant with GLP, GCP and GMP regulations
  • Support the manufacture and release of EIAV/HIV vectors by performing FACS/ELISA analytics in accordance with GMP compliance
  • Perform quality control checks on assay packs for a variety of assay types
  • Support the maintenance of GLP and GMP compliant facilities, performing general laboratory duties, for example calibration, monitoring and cleaning of equipment
  • Drive continuous quality improvement with the compliance with GLP/GCP regulations
  • Assist with the improvement of current assays and the development and validation of new assays
  • Produce and maintain GxP documentation (SOPs, equipment files) to a high standard
  • Share scientific knowledge through regular team/department meetings and presentations

To be successful in this role, you will have the following skills and experience:

  • BSC/PhD or extensive relevant experience in an associated subject
  • Demonstrable knowledge of regulatory requirements e.g. GMP, GLP, GCP and and Quality Management systems and ability to maintain compliance.
  • Competency in performing laboratory tasks and bio-analytical methodologies with expertise in one or more areas e.g. qPCR, nucleic acid extractions, FACS
  • Experience of molecular biology methodologies/techniques.
  • Competency in data capture reporting and management systems e.g. GxP data recording and archiving.
  • Good knowledge/experience of analytical instrumentation e.g. PCR, FACS and some understanding of qualification procedures.
  • Support the development, troubleshooting and validation of analytical methods.
  • Familiar with the literature in defined project area.
  • Capable of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives

No agencies please

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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