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We are currently recruiting for a Scientist IV to join our Vector Engineering Group.  The purpose of this role is to plan, execute and report laboratory-based experiments or analytical investigations in accordance with scientific or regulatory requirements, in alignment with department objectives

Your responsibilities in this role would be:

• To undertake laboratory projects within the Vector Innovation Team towards improved lentiviral vector design
• Technically support broader projects within the Vector Innovation Team and wider Vector Engineering and Platform Research Groups as required
• To be able to work independently and collaboratively according to the requirements of the project
• To maintain knowledge in the field through scientific literature and conferences, and to report back items of interest accordingly
• Accountable for own performance in alignment with group objectives and deadlines. Design and conduct experiments /investigations in accordance with correct methodologies and procedures under the direction of the Group Lead.
• Ensure a high standard of record keeping and documentation of experiments and investigations in order that information is clearly captured and disseminated and reported.
• Present scientific data at internal meetings and external venues such as conferences.
• Will report to the Group Leader or his/her delegated grade 5 to 6 scientist.
• Conduct research and technical support of the highest quality, largely in a single project area but will assist in other projects as the need arises.
• Ensure correct training requirements are met and that the training record is kept correct and up to date
• Ensure experimental data is submitted to PatentSafe in a timely manner.
• May be responsible for maintenance of a laboratory area and/or important equipment.
• Personally responsible for the completion of tasks in relation to their criticality.
• Joint responsibility for maintenance and compliance of a GxP laboratory area and GxP “housekeeping” procedures.
• Work will be conducted in accordance with the OXB quality management system.
• Writing and reviewing of departmental documentation and SOP’s.
• Preparation of reports and documents to support GxP and regulatory activities.

To be successful in this role, you will have the following skills and experience:

• PhD or BSc/MSc Degree in an appropriate discipline with relevant post-qualification experience
• Knowledge in Virology and gene therapy would be an advantage
• Laboratory experience with particular emphasis on one or more of the following: Tissue Culture, qPCR, Molecular Biology, flow cytometry and handling virus/viral vectors
• Demonstrate competency in performing laboratory tasks and general experimental procedures with expertise in protein purification.
• Trained to operate equipment in accordance with OXB procedures and requirements. Responsibility for a single piece of equipment and the ability to troubleshoot.
• Expertise in the use of complex instrumentation eg qPCR, FACS or using difficult biological procedures that requires a specialist knowledge or skill.
• Understanding of laboratory health and safety requirements.
• Sufficient understanding of the overall activities in the department to contribute useful ideas at meetings.
• Familiar with the literature relating to project area.
• Capable of interpreting results from experiments and drawing conclusions but may need guidance from senior scientists.
• Capable of explaining clearly why an experiment is being conducted and how the experiments help the group meet their objectives.
• Good knowledge of the overall research programme in your group.
• Detailed knowledge of the Quality management reporting structure/responsibilities within OXB.
• High regard for safety and display a high level of good laboratory citizenship.
• Detailed knowledge of the regulatory requirements for analytical work (e.g. product specifications, stability testing guidelines etc) is required.

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