Principal Scientist, Team Lead - Upstream

Employer
Oxford BioMedica (UK) Limited
Location
Oxfordshire
Salary
Competitive
Closing date
5 Oct 2020

View more

Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
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Our employees are able to develop their careers in exciting new medical technologies, and so can you.

Oxford Biomedica’s Process R&D team consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for delivery to Manufacturing.

We are currently recruiting for a Principal Scientist, Team Lead - Upstream to join the team.  The purpose of this role is to be responsible for coordinating daily activities to ensure PR&D timelines are met, whilst maintaining compliance with GLP/GMP & safety regulations.

Your responsibilities in this role would be:

  • Responsible for the line management of a team of USP scientists and/or laboratory technicians; including managing performance, motivating the team and carrying out recruitment activities.
    • Manage and prioritise the team’s workload, ensuring results are delivered on time and at a high quality.
    • Ensure all direct reports or persons involved in projects are fully trained and maintain a high standard of record keeping and documentation of experiments so that information is clearly captured, disseminated and reported.
  • Perform, develop and optimise upstream processes for the production of lentiviral vectors, working within the Process R&D group.
  • Involvement in activities ranging from vector manufacture, process optimization, technology transfer, and process validation activities associated with the manufacture of new gene therapy vectors.
  • Provide upstream expertise and contribute to process design and scale-up, to deliver new and improved bio-manufacturing processes based on Quality by Design (QbD) using DoE.
  • Lead the design and execution of experiments/process characterisation/investigations in accordance with correct methodologies, policies and procedures.
  • Responsible for designing and co-ordinating the execution of upstream activities for scale-up/scale-down of existing bioprocesses across multiple bioreactor scales and platforms.
  • Analyse and interpret experimental data and report to stakeholders within OXB and to external clients.
  • As a subject matter expert, contribute to and/or lead troubleshooting and technical investigations as required.
  • Write, revise, review and approve SOPs, technical reports, and risk assessments, where appropriate.
  • Responsible for ensuring the GLP (and where necessary GMP) compliance of the laboratory and equipment.
  • Maintain a safe working environment by ensuring appropriate H&S training, risk assessments and COSHH assessments are in place.
  • Promote appropriate, effective communication within the team, with members of other departments, and with external collaborators.
  • Contribute to cross departmental activities and provide expert advice and technical input where needed.

To be successful in this role, you will have the following skills and experience:

  • BSc, MSc or PhD (or equivalent) in a relevant Bioscience with an appropriate level of relevant experience.
  • Relevant laboratory experience in one or more of the following areas: Tissue Culture, Upstream Bioprocessing, Molecular Biology or Protein Chemistry.
  • Knowledge of bioprocessing scale-up, technology transfer, and/or process characterisation activities highly beneficial for the role.
  • Good understanding of lentiviral vectors (or other gene therapy vectors), and associated product quality attributes.
  • Advanced understanding of cell culture principles and bioprocesses.
  • An understanding of metabolite analysis in the context of mammalian cell culture and media development.
  • Demonstrated experience with suspension cell culture.
  • Experience with the operation of laboratory, pilot or production scale bioreactors.
  • Competency in data capture, reporting and management systems, such as, but not limited to: Microsoft Excel, JMP, Design Expert™, Graphpad Prism
  • Awareness of regulatory requirements e.g. GMP, GLP, GCP, ICH and/or Validation and Quality Management systems.
  • Ability to provide direction and supervision for junior team members and direct reports, to deliver project/group/departmental objectives within the required timeframe.
  • Maintain a high ethical standard and a commitment to producing high quality work.

Do you want to feel inspired every day? We’re future-focused and our business is growing rapidly. We succeed together through passion, commitment and team work, and so can you.

Collaborate. Contribute. Change lives.

No agencies please

About us

We are a pioneering gene therapy business, and our mission is delivering life-changing gene therapies to patients.  We work together, motivated to make a difference, and so can you.

We are pioneers; no one else does what we do

Gene therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells. It is transforming medicine as we know it; long term and potentially curative treatments for a wide range of diseases are now possible.

We are at the forefront of this exciting area. We have a strong reputation in gene therapy, with world-leading expertise in lentiviral vectors. We have a leading, integrated platform of exclusive technologies to design, develop and bioprocess unique gene-based medicines, both in-house and with partners.

We drive credible science to realise incredible results.

Whether you’re motivated by the discovery and development of product candidates within Research, or by cutting edge tools and technologies including AI and automation of our contract development and manufacturing organisation, we can offer you a career like no other. We are excited about our future. Join us and change lives.

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Contact Us
  • Windrush Court
  • Transport Way
  • OX4 6LT
  • United Kingdom
  • +44 (0) 1865 783 000
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