Scientists at AstraZeneca are working every day to turn science fiction into science fact. Our dream - to develop innovative, targeted medicines for every patient that needs them - and to match those treatments to patients most likely to benefit from them - is now becoming a reality. This approach, known as Precision Medicine, is based on those individual characteristics that make some patients respond to treatment better than others. We use this knowledge to develop diagnostic tests that doctors can use to help prescribe the best treatment for each patient. Indeed, it's now become common practice for patients with cancer to be offered such diagnostic tests before their treatment plan is agreed.
We are currently seeking a motivated Senior Clinical Diagnostic Scientist to join the group
This role is responsible for providing scientific and technical expertise as part of the AstraZeneca's Precision Medicine function. You will provide scientific and technical diagnostic expertise and data to drug project teams following a Precision Medicine approach. Specifically, you'll be accountable for leading the delivery of significant work packages of analytical diagnostic validation as agreed with Precision Medicine project representatives. This will include working in collaboration with internal and external partners to design scientific experiments and technical refinements to convert exploratory biomarkers into clinical decision-making diagnostic devices.
You will be responsible for scientific and technical aspects of diagnostic test development, including the selection, quality control and project management of validation activities carried out by specialist laboratories and diagnostic partners. You'll be accountable for ensuring that all activities are delivered demonstrating behaviours and values aligned to AstraZeneca Code of Conduct and supporting policies, standards and procedures, including compliant management of Budget, Safety, Health and Environment.
Accountabilities/Responsibilities, what you will be doing:
- Ensure the quality of science and delivery of analytical diagnostic validation as agreed with Precision Medicine project representatives, including: design of scientific experiments, planning of internal and external validation activities, evaluation of existing options, review of literature and Intellectual Property, technical aspects of partner selection, quality control and project management of deliverables
- Identify opportunities, propose solutions and work across boundaries in the scientific and technical area(s) of expertise that will help drug projects following a Precision Medicine approach to impact across the value chain
- Maintain an intimate knowledge of current and emerging diagnostic technologies in the area of expertise.
- Drive continuous improvement in the scientific and technical area(s) of expertise, aligned to the Precision Medicine strategic objectives
- Be accountable for the time, cost and quality of agreed deliverables
- Provide updates on the progress, risks and opportunities of the agreed deliverables
- Monitor and ensure compliance with all AstraZeneca Policies and Standards and immediately address instances of non-compliance.
Minimum Requirements - Education and Experience:
Minimum required experience:
- PhD or equivalent training in relevant subject
- National level of scientific and technical expertise in own specialist area
- Knowledge of and enthusiasm for the aims and objectives of Precision Medicine
- Has delivered to diagnostic projects within a drug development setting
- Previous experience of working with external partners
- Experience of operating within drug development project including cross-functional working
- Hands-on experience of developing enzyme linked immunoassays (ELISA), including use of regulatory approved platforms
- Expertise in LC-Mass-Spectrometry method validation, including measurement of large and small molecules
- Working in a regulated environment, e.g. Good Clinical Practice or other GxP
- Understanding of related areas of diagnostic validation and drug-diagnostic co-development
- Experience of a similar role as demonstrated by publication record, patents and delivery of biomarker data to projects
- Outsourcing of clinical and regulatory standard laboratory assays
Role can be considered at career levels D or E depending on the suitability and experience of the successful candidate.
Location: Cambridge, UK
Closing Date: 20th September 2020
Next steps, if you feel you are suitable for the role please apply!