Senior Data Scientist
- Employer
- Oxford BioMedica (UK) Limited
- Location
- Oxford
- Salary
- Competitive
- Start date
- 11 Nov 2019
- Closing date
- 9 Dec 2019
View more
- Discipline
- Data Management / Statistics, Biostatistics
- Hours
- Full Time
- Contract Type
- Permanent
- Experience Level
- Experienced (non-manager)
Job Details
Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments.
Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market.
Our recent successes are driving significant growth. As such, we are looking to recruit a Senior Data Scientist (Downstream) to join Process R&D. Within this role, you will support the manufacture of biologics bulk drug substance for commercial and late clinical phase products, through process understanding and applied science. He/She will be responsible for the technical support and optimisation of manufacturing processes for clinical and commercial products, with a particular focus on downstream processing science. He/She will be required to work in close collaboration with other groups within Oxford Biomedica to ensure quality, on-time supply of our products to our patients.
Responsibilities:
- Assist in the technical oversight of downstream unit operations to ensure the development of robust products, processes and analytical methods
- Advise PR&D team on experimental study design using DoE principles
- Use and develop data analysis tools to model and characterise processes in alignment with the QbD principles
- Review, evaluate, and understand downstream process data to deliver robust and reliable process performance and product quality
- Work with the PRD departments to establish statistical methodology and reporting standards
- Establish database rules for collecting, analysing and storing data
- Define/manage systems for process monitoring. Support improvement of data collection and management to enable quick and reliable data analysis
- Identify and drive opportunities for improvements (process capability, yield)
- Contribute to the trouble shooting of complex issues during unit operations through scientific understanding of downstream processes. Assist investigation teams, taking into account production environment constraints and clearly communicate on progress and issues
- Define needs for small/Pilot scale studies supporting late stage development, including execution planning. Write high quality study protocols and reports
- Write technical documents such as SOPS, investigation reports, campaign summary reports
- Present technical analytical data clearly and concisely to business partners
- Identify areas for introduction and development of innovative downstream processing technologies.
Qualifications
- Degree in chemical engineering or biotechnology, although a PhD preferred. Candidates with degrees in mathematics or statistics will also be considered
- Experience in downstream processing is a must. A focus on the scientific understanding of downstream processing (how process inputs, control parameters, and environment, influences process performance and product quality) is sought
- Experience in one or more of the following areas is a must: analysis of data sets to identify process performance issues/opportunities (e.g., MVDA), -omics, design of experiments
- Experience in data modelling and data enrichment techniques
- The capacity to develop and document procedures and workflows
- Experience of process validation, resolution of complex (technical, stakeholder) technical issues impacting commercial production or late stage process development
- Demonstrable professional experience in downstream process development in the biopharmaceutical industry at large or small scale. Experience in GMP production highly desirable
- A strong skill set in analysis of downstream performance data sets (using online and offline data to understand process behaviour and resolve processing issues)
No agencies please
Company
Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.
Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).
Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise.
Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.com, www.oxbsolutions.com, and follow us on LinkedIn, Twitter and YouTube.
Life at Oxford Biomedica
We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.
Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.
No matter who you are, or what you do, your work will make a significant difference.
We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.
We have access to like-minded scientists and engineers, working in the latest technologies.
Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.
Our supportive culture invites talent, while creating future innovators.
We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning. Our defined career pathways provide opportunities for everyone to achieve their career potential. We make a difference, and so can you.
- Website
- http://www.oxb.com/
- Telephone
- +44 (0) 1865 783 000
- Location
-
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom
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