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Team Lead, Upstream

Employer
Oxford BioMedica (UK) Limited
Location
Oxford
Salary
Competitive
Start date
11 Nov 2019
Closing date
9 Dec 2019

View more

Discipline
R & D
Hours
Full Time
Contract Type
Permanent
Experience Level
Management

Job Details

Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments.

Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market.

Our recent successes are driving significant growth. As such, we are looking to recruit a Team Lead, Upstream to join our Process R&D leadership team.  In this role, you will be accountable for the effective high performance of a team of scientists, with a tactical focus on day to day management.

Key responsibilities and accountabilities:

  • Provide line management to a team of scientists to contribute to the overall group objectives in line with company objectives.
  • Be responsible for day to day operations within the team.
  • Ensure all direct reports or persons involved in projects are fully trained and maintain a high standard of record keeping and documentation of experiments so that information is clearly captured, disseminated and reported.
  • With Group Lead, ensure processes are developed with a view to application within GMP Manufacturing.
  • Maintain awareness of upcoming technologies, and keep up to date with current literature and thinking.
  • Provide upstream expertise and contribute to process design and scale-up, to deliver new and improved bio-manufacturing processes based on Quality by Design (QbD) using DoE, which can be operated within a GMP environment profile.
  • Progress the process development projects, optimisation and scale-up activities for the manufacture of gene-based medicines (both internal and external programs).
  • Support the development and implementation of manufacturing processes/continuous improvement programmes.
  • Contribute to the training and development of others.
  • Promote appropriate, effective communication within team, with members of other departments, and with external collaborators.
  • Contribute to cross departmental activities and providing expert advice and technical input where needed.
  • Understand the health and safety aspects of the work carried out in their team.

Key skills and requirements:

  • Postgraduate degree (or equivalent level qualification) in a relevant science
  • Indepth experience in executing upstream projects/activities
  • Proven line management experience
  • Excellent written and verbal communication skills
  • Excellent organisational and time management skills
  • Ability to prioritise workloads and work under pressure
  • Good attention to detail
  • Highly self-motivated

Person Specification:

  • Experience in process design, optimisation and scale-up of bioprocesses to support clinical development.
  • Practical knowledge of process characterisation / validation.

About Process Research & Development

The Process R&D group has a core function within Manufacturing Development.  It consists of experienced scientists and engineers that have extensive expertise in all aspects of upstream and downstream development.  PR&D take processes from the laboratory “bench” scale and apply process expertise and engineering fundamentals for systematic evaluation, optimisation and understanding for delivery to Manufacturing. As the focus shifts towards delivering processes and materials to support our LentiVector® platform products through later-stage development and market supply, PR&D is well positioned to ensure our products are manufactured using processes that are scalable, robust and reproducible as well as commercially viable and regulatory compliant.

Please note that applications will only be reviewed once a CV has been attached and the Questionnaire has been completed.

No agencies please

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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