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Scientist IV, Analytical Development Group

Employer
Oxford BioMedica (UK) Limited
Location
Oxford
Salary
Competitive
Start date
8 Nov 2019
Closing date
6 Dec 2019

View more

Discipline
R & D , Scientific
Hours
Full Time
Contract Type
Permanent
Experience Level
Experienced (non-manager)

Job Details

Oxford BioMedica is a pioneer of gene and cell therapy and our work is helping to deliver life changing treatments.

Gene and cell therapy is the treatment of disease by the delivery of therapeutic DNA into a patient’s cells, providing long term and potentially curative treatments for a wide range of diseases. With the potential to transform medicine, the sector holds significant promise with the first commercial products now launched and others rapidly approaching the market.

Oxford Biomedica’s Analytical Development group is seeking to expand and strengthen its team by recruiting an experienced scientist to support the development validation needs of an increasing portfolio of cell and gene therapies. The group is responsible for assay development and subsequent validation to support the GMP manufacturing process and early phase development through to commercialisation. The role requires the ability to work in a multi-disciplined innovative environment whilst also adhering to internal and external quality systems. The Analytical Development Group is part of the research group but works closely with manufacturing, clinical and analytical services at all stages of development.

A highly motivated individual is sought to work within this team. The successful candidate will be expected to:

  • Perform validation of new and existing assays and equipment to support the development of Oxford Biomedica’s pipeline
  • Evaluate and implement new technologies to improve the performance and efficiency of analytical work streams
  • Support the development and clinical manufacture of ATMPs 

Key responsibilities and accountabilities:

  • Identifying, evaluating and validating new analytical methods and technologies within a GMP environment
  • Troubleshoot assay performance issues as and when required
  • Drafting and preparation of standard operating procedures for new assays and updating existing ones following validation
  • Act as project manager for validation and qualification studies, training members of the Analytical Services Group (ASG) to perform newly developed and validated assays
  • Assist with other activities undertaken in the research group as required

Key skills and requirements:

  • Strong biochemistry and molecular biology skills especially around, but not limited to, DNA, RNA, quantitative PCR and/or protein analysis from a minimum of BSc or MSc in Biochemistry, Biotechnology, Molecular Biology or Analytical Science and industry experience
  • Practical industry experience in analytics and development projects/activities
  • Experience of working in a regulated environment  (GMP/GLP/GCLP)
  • A strong background in assay development and validation
  • Knowledge of ICH guidelines would be desirable

Person Specification:

  • Good level of presentation as well as written and verbal communication skills
  • A highly motivated individual with the proven ability to work collaboratively both independently as well as in a team
  • Have excellent planning and organisational and time management skills
  • Ability to undertake projects to agreed timelines and adapt to rapid changes in project priorities
  • The ability to train others in the conduct of analytical techniques

No agencies please

Company

Oxford Biomedica is a quality and innovation-led viral vector CDMO that enables its clients to deliver life-changing therapies to patients around the world. One of the original pioneers in cell and gene therapy, Oxford Biomedica has more than 25 years of experience in viral vectors, the driving force behind the majority of gene therapies.  

Cell and gene therapy is the treatment of disease by the delivery of therapeutic genetic material (DNA or RNA), into a patient’s cells. One highly effective approach to delivering genetic information is to re-engineer existing viruses to be safe delivery vehicles (vectors) to insert the genetic material into patients’ cells. This can be achieved either by directly administering the vector to the patient (often referred to as in vivo gene therapy), or by first introducing the genetic material to cells or tissue outside of the body, before administering the cells or tissue into the patient (often referred to as ex vivo gene therapy or gene-modified cell therapy).  

Oxford Biomedica collaborates with some of the world's most innovative pharmaceutical and biotechnology companies, providing viral vector development and manufacturing expertise in lentivirus, adeno-associated virus (AAV) and adenoviral vectors. Oxford Biomedica's world-class capabilities span from early-stage development to commercialisation. These capabilities are supported by robust quality-assurance systems, analytical methods and depth of regulatory expertise. 

Oxford Biomedica, a FTSE4Good constituent, is headquartered in Oxford, UK. It has locations across Oxfordshire, UK and near Boston, MA, US. Learn more at www.oxb.comwww.oxbsolutions.com, and follow us on LinkedInTwitter and YouTube

Life at Oxford Biomedica

We value everyone’s unique contribution, we appreciate everyone’s individuality, and every job matters.

Your contributions are recognised and appreciated. Your work-life balance matters. We recognise, develop and use your strengths. It’s a place where you are valued as a whole person, as an individual and as part of a team.

No matter who you are, or what you do, your work will make a significant difference.

We go the extra mile, every day, because we truly care. We work together as a team to achieve our life changing therapies. Our talented colleagues help to build other people’s futures, so can you. We empower each other to be our best.

We have access to like-minded scientists and engineers, working in the latest technologies.

Our community of experts create new life-saving cures. Shaping the business’ future through collaboration. Our people are on a continuous professional development journey aided by a thought-provoking environment. A place for experts to be stretched, and future experts to be nurtured. We inspire creativity and deliver great science, and so can you.

Our supportive culture invites talent, while creating future innovators.

We’ll give you a place where you can learn, grow and contribute to the future of cell and gene therapy. We create opportunities and invest in our people, promoting ongoing learning.  Our defined career pathways provide opportunities for everyone to achieve their career potential.  We make a difference, and so can you.

Company info
Website
Telephone
+44 (0) 1865 783 000
Location
Windrush Court
Transport Way
Oxford
OX4 6LT
United Kingdom

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