Your Responsibilities:
We are seeking an experienced and highly motivated in vitro scientist that has a background in automation. Joining a fast-paced discovery DMPK in vitro team in Stevenage, you’ll be reporting to the in vitro team leader and will be primarily responsible for implementing in vitro mechanistic studies and generating ADME data to aid in the lead optimization, precandidate profiling and the clinical translation of NCEs and to provide information to develop predict first models to aid medicinal chemistry design. As someone who thrives on challenges and change you will be able to work across matrix teams and manage multiple complex projects at once.

Working with a DMPK team you will help to solve bespoke in vitro ADME project issues and therefore a background in transporters or enzymology is required. Utilising state of the art automation you will be responsible for leading the science by implementing and validating in vitro assays and exploring novel technologies for generating in vitro data. This role will be heavily reliant on automation and a strong background in end to end automation including liquid handling robotics (e.g. Hamilton STAR) is desired.

The position will be responsible for the delivery of in vitro DMPK data that will influence and direct new chemistry during the design-make-test cycle and discovery and development project direction. The role will include leading and delivering scientific excellence with an ability to work independently across multiple complex and matrix team based challenges.

Key Responsibilities include, but are not limited to:
• Designing, implementing and validating in vitro ADME assays on liquid handling robotics
• Managing the generation of routine in vitro DMPK screening assays to generate high quality and timely data
• Contributing to the development, evaluation and implementation of novel technologies to generate ADMET preclinical data
• Training staff within the DMPK department in, in vitro ADME sciences and automation
• Working with DMPK project team representatives to solve bespoke in vitro ADME project issues
• Collaborating with a counterpart in vitro DMPK group in the U.S. to implement a global in vitro strategy.
• Representing the in vitro team at cross functional meetings
• Engaging with business partners and providing recommendations based on generated data
• Responsibility for developing and applying adequate knowledge of in vitro ADME sciences to keep up to date with latest industry trends.
• Innovation and problem-solving to overcome in vitro assay design issues.
• Decision making and influencing skills in a DMPK environment, contextualizing data with respect to developability and predicted human parameters, including dose.
• Ensuring data generated, from within and external to GSK, meets appropriate standards and that archiving & data integrity compliance is achieved.

Closing Date for Applications: Friday 15th November COB

Please take a copy of the Job Description, as this will not be available post closure of the advert.

When applying for this role, please use the ‘cover letter’ of the online application or your CV to describe how you meet the competencies for this role, as outlined in the job requirements above. The information that you have provided in your cover letter and CV will be used to assess your application.

During the course of your application you will be requested to complete voluntary information which will be used in monitoring the effectiveness of our equality and diversity policies. Your information will be treated as confidential and will not be used in any part of the selection process.  If you require a reasonable adjustment to the application / selection process to enable you to demonstrate your ability to perform the job requirements please contact 0808 234 4391. This will help us to understand any modifications we may need to make to support you throughout our selection process.
*LI-GSK
GSKGenetics

Why You?

Basic qualifications:
• BSc or equivalent degree in Life sciences or related science such as Drug Metabolism, Pharmacology, Biology, Toxicology, Biochemistry, Physiology
• Extensive experience, up to date knowledge and excellence in the area of in vitro ADME sciences
• Experience of automation and liquid handling robotics in a drug discovery environment
• Strong understanding of key DMPK disciplines
• Proven ability to integrate and interpret in vitro ADME data
• Extensive experience working in a fast-paced pharmaceutical or CRO environment
• Experience of report writing for key decision documents
• Excellent communication, interpersonal and team working skills

Preferred qualifications:
• MSc or PhD in relevant discipline
• Experience in programming Hamilton software (Venus)
• Experience of handling cell-based systems (aseptic) techniques will be an advantage
• Experience of operating and knowledge of LC-MS/MS

Why GSK?:
GlaxoSmithKline is a science-led global healthcare company that researches and develops a broad range of innovative medicines and brands. We discover, make and market life-enhancing products that are used by millions of people around the world, helping them to do more, feel better and live longer. We have 3 primary areas of business in pharmaceuticals, vaccines and consumer healthcare. We have offices in more than 115 countries, major research centers in the UK, USA, Spain, Belgium and China and an extensive manufacturing network with 87 sites globally. Our three strategic priorities are to grow a diversified global business, deliver products of value, and to simplify our operating model.

Contact information:
You may apply for this position online by selecting the Apply now button.

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